Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CBX4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CBX4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CBX4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:79,832,138–79,833,014 | 6.4 kb | Proximal (<10kb) | 657 | |
| chr17:79,834,107–79,837,863 | 1.6 kb | Proximal (<10kb) | 885 | |
| chr17:79,838,651–79,840,856 | at TSS | At TSS | 954 | |
| chr17:79,843,229–79,843,499 | 3.8 kb | Proximal (<10kb) | 148 | |
| chr17:79,843,937–79,844,419 | 4.5 kb | Proximal (<10kb) | 667 | |
| chr17:79,844,848–79,845,258 | 5.4 kb | Proximal (<10kb) | 597 |
Genomic view of the CBX4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.