This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HOXB13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HOXB13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HOXB13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:48,718,468–48,719,563 | 9.2 kb | Proximal (<10kb) | 164 | |
| chr17:48,719,708–48,720,337 | 8.4 kb | Proximal (<10kb) | 181 | |
| chr17:48,722,219–48,723,762 | 5.0 kb | Proximal (<10kb) | 220 | |
| chr17:48,724,560–48,724,774 | 4.0 kb | Proximal (<10kb) | 101 | |
| chr17:48,728,286–48,729,570 | at TSS | At TSS | 376 | |
| chr17:48,732,776–48,733,593 | 4.0 kb | Proximal (<10kb) | 298 |
Genomic view of the HOXB13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.