chr1:25,847,840–25,848,970

chr1 : 25,847,840 – 25,848,970

1,130 bp 94 TFs 8 linked genes

This 1.1 kb open chromatin element is linked to 8 target genes and is bound by 94 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
AUNIP		10.9 kb	Distal	Multiome
PAQR7		27.1 kb	Distal	Multiome
MTFR1L		28.6 kb	Distal	Multiome
SELENON		48.4 kb	Distal	Multiome
STMN1		57.8 kb	Distal	Multiome
PAFAH2		149.5 kb	Distal	Multiome+HiCAR
MAN1C1		231.8 kb	Distal	Multiome
PDIK1L		263.2 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

94 transcription factors

ChIP HeLa GSE40632.AFF4.HeLa 149 bp overlap

ATF3 3 datasets

ChIP HCT-116_CAMP GSE74355.ATF3.HCT-116_CAMP 102 bp overlap

ChIP K-562 ENCSR028UIU.ATF3.K-562 231 bp overlap

ChIP K562 ENCFF604FPV 487 bp overlap

ChIP CD4_JG1 GSE33281.BRD4.CD4_JG1 106 bp overlap

ChIP PC-3_DAXX GSE68647.DAXX.PC-3_DAXX 162 bp overlap

DMRTA1 1 dataset

Motif DE_72h DE_72h-DMRTA1_MA1707.2 10 bp overlap

DMRTA2 1 dataset

Motif DE_72h DE_72h-DMRTA2_MA1478.2 6 bp overlap

DMRTC2 1 dataset

Motif DE_72h DE_72h-DMRTC2_MA1479.2 11 bp overlap

DPRX 3 datasets

Motif DE_48h DE_48h-DPRX_MA1480.2 9 bp overlap

Motif DE_60h DE_60h-DPRX_MA1480.2 9 bp overlap

Motif DE_72h DE_72h-DPRX_MA1480.2 9 bp overlap

Dmrt1 1 dataset

Motif DE_48h DE_48h-Dmrt1_MA1603.2 9 bp overlap

EOMES 2 datasets

ChIP hESC GSE26097.EOMES.hESC 276 bp overlap

ChIP hESC GSE26097.EOMES.hESC 326 bp overlap

ChIP aortic-endothelial-cell_D16 GSE139377.ERG.aortic-endothelial-cell_D16 215 bp overlap

ChIP aortic-endothelial-cell_D33 GSE139377.ERG.aortic-endothelial-cell_D33 187 bp overlap

ChIP SU-DHL-5 GSE45982.EZH2.SU-DHL-5 132 bp overlap

FEZF1 1 dataset

ChIP HEK293 GSE76494.FEZF1.HEK293 141 bp overlap

FIGLA 1 dataset

Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap

ChIP endothelial cell of umbilical vein ENCFF415XBG 401 bp overlap

ChIP endothelial_umbilical-vein ENCSR000EVU.FOS.endothelial_umbilical-vein 383 bp overlap

FOSL1 3 datasets

ChIP 143B GSE74230.FOSL1.143B 215 bp overlap

ChIP K562 ENCFF455MKD 655 bp overlap

ChIP MDA-MB-231 GSE95303.FOSL1.MDA-MB-231 148 bp overlap

FOXA2 3 datasets

ChIP BJ1-hTERT_MimoRelease GSE92491.FOXA2.BJ1-hTERT_MimoRelease 259 bp overlap

ChIP DE DE-FOXA2-1 1130 bp overlap

ChIP DE DE-FOXA2-2 1130 bp overlap

FOXO1-PAX3 1 dataset

ChIP RH4_DMSO-6H GSE116344.FOXO1-PAX3.RH4_DMSO-6H 208 bp overlap

GATA1 1 dataset

ChIP K-562 GSE107726.GATA1.K-562 225 bp overlap

GATA1::TAL1 2 datasets

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA4 7 datasets

ChIP BJ1-hTERT GSE92491.GATA4.BJ1-hTERT 324 bp overlap

ChIP DE DE-GATA4-1 1099 bp overlap

ChIP DE DE-GATA4-2 1102 bp overlap

ChIP foregut GSE117136.GATA4.foregut 1010 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 996 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 514 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 274 bp overlap

GATA6 14 datasets

ChIP DE DE-GATA6-1 1035 bp overlap

ChIP DE DE-GATA6-2 1130 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 1063 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 1038 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 1049 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 1066 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 1025 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 1045 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 1057 bp overlap

ChIP foregut GSE117136.GATA6.foregut 939 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 487 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 904 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 448 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 387 bp overlap

HDAC2 1 dataset

ChIP K-562 ENCSR000BMG.HDAC2.K-562 122 bp overlap

HDAC3 1 dataset

ChIP RH4_DMSO-6H GSE116344.HDAC3.RH4_DMSO-6H 213 bp overlap

ChIP K-562 ENCSR197ALX.HDGF.K-562 361 bp overlap

HOXB13 1 dataset

ChIP G-401 GSE65381.HOXB13.G-401 262 bp overlap

Motif DE_72h DE_72h-Hic1_MA0739.2 8 bp overlap

IRF2BP2 1 dataset

ChIP HEK293 GSE124636.IRF2BP2.HEK293 91 bp overlap

IRF4 2 datasets

ChIP NCI-H929 GSE56857.IRF4.NCI-H929 125 bp overlap

ChIP NCI-H929 GSE142493.IRF4.NCI-H929 85 bp overlap

Motif DE_72h DE_72h-Irf1_MA0050.4 11 bp overlap

JUN 11 datasets

ChIP DE_D1 S08-DE-d1-JUN-exp1 434 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 477 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 448 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 748 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 295 bp overlap

ChIP HAEC_IL1b_4h GSE89970.JUN.HAEC_IL1b_4h 233 bp overlap

ChIP HAEC_TNFa_4h GSE89970.JUN.HAEC_TNFa_4h 286 bp overlap

ChIP HAEC_oxpapc_4h GSE89970.JUN.HAEC_oxpapc_4h 130 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 458 bp overlap

ChIP endothelial cell of umbilical vein ENCFF791BMV 297 bp overlap

ChIP endothelial_umbilical-vein ENCSR000EFA.JUN.endothelial_umbilical-vein 159 bp overlap

JUNB 2 datasets

ChIP CFPAC-1 GSE119930.JUNB.CFPAC-1 279 bp overlap

ChIP HAEC GSE89970.JUNB.HAEC 280 bp overlap

KDM1A 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.KDM1A.pancreatic-progenitor_PP1 255 bp overlap

ChIP K562 ENCFF340MHH 545 bp overlap

ChIP MDA-MB-468 GSE81381.MAX.MDA-MB-468 175 bp overlap

Motif DE_48h DE_48h-MAZ_MA1522.2 8 bp overlap

MEIS1 1 dataset

Motif DE_48h DE_48h-MEIS1_MA1639.2 9 bp overlap

MEIS2 1 dataset

Motif DE_48h DE_48h-MEIS2_MA1640.2 9 bp overlap

MRTFB 1 dataset

ChIP A-673-clone-Asp114 GSE92738.MRTFB.A-673-clone-Asp114 293 bp overlap

Motif DE_72h DE_72h-MYB_MA0100.4 6 bp overlap

ChIP P493-6_SHCTR GSE60223.MYC.P493-6_SHCTR 164 bp overlap

ChIP U2OS_Doxy GSE44672.MYC.U2OS_Doxy 82 bp overlap

ChIP endothelial_umbilical-vein ENCSR000DLU.MYC.endothelial_umbilical-vein 124 bp overlap

MYOD1 6 datasets

ChIP RD_shSNAI2 GSE137168.MYOD1.RD_shSNAI2 187 bp overlap

ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 303 bp overlap

ChIP RH4 GSE83726.MYOD1.RH4 199 bp overlap

ChIP SMS-CTR GSE137168.MYOD1.SMS-CTR 216 bp overlap

ChIP myoblast GSE50413.MYOD1.myoblast 263 bp overlap

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 181 bp overlap

Motif DE_72h DE_72h-NFIA_MA0670.2 6 bp overlap

Motif DE_72h DE_72h-NFIX_MA0671.2 6 bp overlap

NR2F2 1 dataset

ChIP K-562 ENCSR000BRS.NR2F2.K-562 123 bp overlap

ChIP fetal_testis GSE100639.PAX5.fetal_testis 187 bp overlap

PBX2 2 datasets

Motif DE_48h DE_48h-PBX2_MA1113.3 9 bp overlap

ChIP K562 ENCFF286KMN 417 bp overlap

PHOX2B 1 dataset

Motif DE_48h DE_48h-PHOX2B_MA0681.3 12 bp overlap

PKNOX1 2 datasets

ChIP HEK293T ENCFF174WDB 356 bp overlap

ChIP HEK293T ENCSR233FAG.PKNOX1.HEK293T 269 bp overlap

PRDM10 1 dataset

ChIP HEK293 ENCFF145WQQ 407 bp overlap

PRDM4 2 datasets

ChIP HEK293 ENCFF069PHD 373 bp overlap

ChIP HEK293 ENCSR443MVV.PRDM4.HEK293 260 bp overlap

PSIP1 1 dataset

ChIP T-REx-293 GSE117155.PSIP1.T-REx-293 234 bp overlap

Motif DE_72h DE_72h-REL_MA0101.1 10 bp overlap

RELA 18 datasets

Motif DE_72h DE_72h-RELA_MA0107.1 10 bp overlap

ChIP HAEC_IL1b_4h GSE89970.RELA.HAEC_IL1b_4h 156 bp overlap

ChIP HAEC_TNFa_4h GSE89970.RELA.HAEC_TNFa_4h 198 bp overlap

ChIP aortic-endothelial-cell_IL1B_D10 GSE139377.RELA.aortic-endothelial-cell_IL1B_D10 170 bp overlap

ChIP aortic-endothelial-cell_IL1B_D13 GSE139377.RELA.aortic-endothelial-cell_IL1B_D13 267 bp overlap

ChIP aortic-endothelial-cell_IL1B_D14 GSE139377.RELA.aortic-endothelial-cell_IL1B_D14 471 bp overlap

ChIP aortic-endothelial-cell_IL1B_D16 GSE139377.RELA.aortic-endothelial-cell_IL1B_D16 324 bp overlap

ChIP aortic-endothelial-cell_IL1B_D2 GSE139377.RELA.aortic-endothelial-cell_IL1B_D2 211 bp overlap

ChIP aortic-endothelial-cell_IL1B_D21 GSE139377.RELA.aortic-endothelial-cell_IL1B_D21 186 bp overlap

ChIP aortic-endothelial-cell_IL1B_D26 GSE139377.RELA.aortic-endothelial-cell_IL1B_D26 258 bp overlap

ChIP aortic-endothelial-cell_IL1B_D4 GSE139377.RELA.aortic-endothelial-cell_IL1B_D4 215 bp overlap

ChIP aortic-endothelial-cell_IL1B_D40 GSE139377.RELA.aortic-endothelial-cell_IL1B_D40 160 bp overlap

ChIP aortic-endothelial-cell_IL1B_D45 GSE139377.RELA.aortic-endothelial-cell_IL1B_D45 259 bp overlap

ChIP aortic-endothelial-cell_IL1B_D47 GSE139377.RELA.aortic-endothelial-cell_IL1B_D47 203 bp overlap

ChIP aortic-endothelial-cell_IL1B_D49 GSE139377.RELA.aortic-endothelial-cell_IL1B_D49 301 bp overlap

ChIP aortic-endothelial-cell_IL1B_D53 GSE139377.RELA.aortic-endothelial-cell_IL1B_D53 314 bp overlap

ChIP aortic-endothelial-cell_IL1B_D7 GSE139377.RELA.aortic-endothelial-cell_IL1B_D7 356 bp overlap

ChIP aortic-endothelial-cell_IL1B_D9 GSE139377.RELA.aortic-endothelial-cell_IL1B_D9 405 bp overlap

RFX1 4 datasets

ChIP K-562 ENCSR968GIB.RFX1.K-562 424 bp overlap

ChIP K-562 ENCSR041AXL.RFX1.K-562 394 bp overlap

ChIP K562 ENCFF421AVO 308 bp overlap

ChIP K562 ENCFF809XVG 251 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 801 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 615 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 270 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 511 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 989 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 665 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 177 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 198 bp overlap

SMARCA4 2 datasets

ChIP TTC-1240_delC GSE124903.SMARCA4.TTC-1240_delC 214 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 272 bp overlap

SMARCB1 1 dataset

ChIP hiPSC GSE124903.SMARCB1.hiPSC 180 bp overlap

SMARCC1 5 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 352 bp overlap

ChIP G-401_Dox GSE71504.SMARCC1.G-401_Dox 165 bp overlap

ChIP SCCOHT-1 GSE117734.SMARCC1.SCCOHT-1 172 bp overlap

ChIP TTC-1240_delC GSE124903.SMARCC1.TTC-1240_delC 213 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 230 bp overlap

SOX14 1 dataset

Motif DE_48h DE_48h-SOX14_MA1562.2 9 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 477 bp overlap

SOX21 1 dataset

Motif DE_48h DE_48h-SOX21_MA0866.1 15 bp overlap

SOX8 2 datasets

Motif DE_48h DE_48h-SOX8_MA0868.3 7 bp overlap

ChIP RH4_Entinostat-6H GSE116344.SOX8.RH4_Entinostat-6H 125 bp overlap

Motif DE_48h DE_48h-SRY_MA0084.2 7 bp overlap

Motif DE_48h DE_48h-Sox1_MA0870.1 15 bp overlap

Motif DE_48h DE_48h-Sox5_MA0087.3 8 bp overlap

Motif DE_72h DE_72h-Sox6_MA0515.1 10 bp overlap

Stat2 1 dataset

Motif DE_72h DE_72h-Stat2_MA1623.2 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 183 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 378 bp overlap

TAF1 2 datasets

ChIP SK-N-SH ENCFF630ERV 297 bp overlap

ChIP SK-N-SH ENCSR000BQF.TAF1.SK-N-SH 112 bp overlap

TEAD1 2 datasets

Motif DE_72h DE_72h-TEAD1_MA0090.4 9 bp overlap

ChIP pancreas_12D ERP008682.TEAD1.pancreas_12D 190 bp overlap

TEAD2 1 dataset

Motif DE_72h DE_72h-TEAD2_MA1121.2 7 bp overlap

TEAD3 1 dataset

Motif DE_72h DE_72h-TEAD3_MA0808.1 8 bp overlap

TEAD4 1 dataset

Motif DE_72h DE_72h-TEAD4_MA0809.3 8 bp overlap

ChIP HUVEC-C GSE88894.TFEB.HUVEC-C 274 bp overlap

TRIM28 2 datasets

ChIP HEK293 ENCFF265CEM 516 bp overlap

ChIP HEK293 ENCFF582MWI 652 bp overlap

ChIP Hep-G2_RBM25-KD GSE120104.YY1.Hep-G2_RBM25-KD 341 bp overlap

ChIP RH4_DMSO-6H GSE116344.YY1.RH4_DMSO-6H 277 bp overlap

ZBTB7A 1 dataset

ChIP K-562 GSE103445.ZBTB7A.K-562 222 bp overlap

ZEB1 2 datasets

Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap

ChIP HEK293 ENCSR909HMT.ZEB1.HEK293 251 bp overlap

ChIP HEK293 ENCSR417VWF.ZEB2.HEK293 350 bp overlap

ZNF143 1 dataset

ChIP FLP143HA_T4 GSE39263.ZNF143.FLP143HA_T4 145 bp overlap

ZNF22 1 dataset

ChIP HEK293 GSE76494.ZNF22.HEK293 252 bp overlap

ZNF30 1 dataset

ChIP HEK293 GSE76494.ZNF30.HEK293 176 bp overlap

ZNF335 1 dataset

ChIP HEK293 ENCSR328SUD.ZNF335.HEK293 250 bp overlap

ZNF485 1 dataset

ChIP HEK293T GSE78099.ZNF485.HEK293T 161 bp overlap

ZNF506 1 dataset

ChIP HEK293T GSE78099.ZNF506.HEK293T 230 bp overlap

ZNF528 1 dataset

ChIP HEK293 GSE76494.ZNF528.HEK293 188 bp overlap

ZNF554 1 dataset

ChIP HEK293 GSE76494.ZNF554.HEK293 146 bp overlap

ZNF652 1 dataset

ChIP Hep-G2 ENCSR502GAX.ZNF652.Hep-G2 114 bp overlap

ZNF660 1 dataset

ChIP HEK293 ENCSR283DOU.ZNF660.HEK293 197 bp overlap

ZNF75A 1 dataset

Motif DE_72h DE_72h-ZNF75A_MA2097.1 12 bp overlap