Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF485. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF485 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF485, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:43,322,425–43,323,518 | 283.5 kb | Distal (>10kb) Multiome | 215 | |
| chr10:43,361,820–43,362,935 | 244.0 kb | Distal (>10kb) Multiome | 416 | |
| chr10:43,395,694–43,397,607 | 209.3 kb | Distal (>10kb) Multiome | 1120 | |
| chr10:43,407,131–43,410,086 | 197.2 kb | Distal (>10kb) Multiome | 1109 | |
| chr10:43,420,185–43,421,230 | 185.7 kb | Distal (>10kb) Multiome | 1071 | |
| chr10:43,436,316–43,437,609 | 169.5 kb | Distal (>10kb) Multiome | 970 | |
| chr10:43,455,021–43,456,361 | 150.7 kb | Distal (>10kb) Multiome | 973 | |
| chr10:43,573,680–43,574,942 | 31.9 kb | Distal (>10kb) Multiome | 675 | |
| chr10:43,606,127–43,607,204 | 109 bp | At TSS Multiome | 620 | |
| chr10:43,648,129–43,649,499 | 42.4 kb | Distal (>10kb) Multiome | 698 | |
| chr10:43,689,359–43,690,800 | 83.8 kb | Distal (>10kb) Multiome | 520 |
Genomic view of the ZNF485 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.