Predicted to enable DNA binding activity. Predicted to be involved in regulation of gene expression. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:44,857,501–44,858,355 | 143.0 kb | Distal (>10kb) Multiome | 448 | |
| chr10:44,864,146–44,865,652 | 135.9 kb | Distal (>10kb) Multiome | 522 | |
| chr10:44,878,575–44,879,826 | 122.0 kb | Distal (>10kb) Multiome | 240 | |
| chr10:44,910,983–44,911,566 | 89.7 kb | Distal (>10kb) Multiome | 286 | |
| chr10:44,932,558–44,933,348 | 68.0 kb | Distal (>10kb) Multiome | 412 | |
| chr10:44,959,053–44,960,601 | 41.3 kb | Distal (>10kb) Multiome | 776 | |
| chr10:44,974,599–44,975,440 | 25.8 kb | Distal (>10kb) Multiome | 563 | |
| chr10:44,978,302–44,979,560 | 22.0 kb | Distal (>10kb) Multiome | 816 | |
| chr10:45,000,712–45,001,661 | 94 bp | At TSS Multiome | 587 | |
| chr10:45,008,513–45,008,925 | 7.6 kb | Proximal (<10kb) | 367 | |
| chr10:45,249,912–45,250,539 | 249.0 kb | Distal (>10kb) Multiome HiCAR | 197 |
Genomic view of the ZNF22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.