Enables transcription coactivator activity. Involved in positive regulation of miRNA transcription; positive regulation of striated muscle tissue development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; postsynapse; and presynapse. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MRTFB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRTFB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRTFB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:13,919,372–13,920,619 | 327.4 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr16:14,070,605–14,071,845 | 176.2 kb | Distal (>10kb) Multiome | 900 | |
| chr16:14,285,067–14,286,457 | 38.4 kb | Distal (>10kb) Multiome | 1045 | |
| chr16:14,301,483–14,303,129 | 54.9 kb | Distal (>10kb) Multiome | 617 | |
| chr16:14,405,593–14,406,150 | 158.4 kb | Distal (>10kb) Multiome | 514 |
Genomic view of the MRTFB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.