This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PAFAH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAFAH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAFAH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:24,929,080–24,930,934 | 1067.8 kb | Distal (>10kb) Multiome HiCAR | 414 | |
| chr1:24,931,551–24,932,717 | 1065.7 kb | Distal (>10kb) Multiome HiCAR | 362 | |
| chr1:25,707,237–25,707,853 | 290.7 kb | Distal (>10kb) Multiome | 136 | |
| chr1:25,799,785–25,800,844 | 198.0 kb | Distal (>10kb) Multiome | 369 | |
| chr1:25,819,447–25,821,126 | 178.1 kb | Distal (>10kb) Multiome HiCAR | 904 | |
| chr1:25,831,516–25,832,168 | 166.2 kb | Distal (>10kb) Multiome | 89 | |
| chr1:25,847,840–25,848,970 | 149.5 kb | Distal (>10kb) Multiome HiCAR | 94 | |
| chr1:25,858,921–25,859,851 | 138.7 kb | Distal (>10kb) Multiome | 881 | |
| chr1:25,874,962–25,876,490 | 122.5 kb | Distal (>10kb) Multiome HiCAR | 888 | |
| chr1:25,895,422–25,895,979 | 102.5 kb | Distal (>10kb) Multiome HiCAR | 500 | |
| chr1:25,905,055–25,907,219 | 92.5 kb | Distal (>10kb) Multiome HiCAR | 917 | |
| chr1:25,922,512–25,923,426 | 75.3 kb | Distal (>10kb) Multiome | 386 | |
| chr1:25,968,758–25,969,159 | 29.2 kb | Distal (>10kb) Multiome | 17 | |
| chr1:25,997,628–25,998,708 | 117 bp | At TSS Multiome | 1091 | |
| chr1:26,021,572–26,022,167 | 23.6 kb | Distal (>10kb) Multiome | 231 | |
| chr1:26,034,958–26,036,424 | 38.0 kb | Distal (>10kb) Multiome | 780 | |
| chr1:26,045,386–26,046,127 | 47.8 kb | Distal (>10kb) Multiome | 178 | |
| chr1:26,093,947–26,095,162 | 96.1 kb | Distal (>10kb) Multiome | 403 | |
| chr1:26,110,626–26,112,596 | 113.7 kb | Distal (>10kb) Multiome | 934 | |
| chr1:26,161,287–26,162,232 | 163.7 kb | Distal (>10kb) Multiome | 564 | |
| chr1:26,164,134–26,165,044 | 166.4 kb | Distal (>10kb) Multiome | 500 | |
| chr1:26,169,358–26,170,373 | 171.8 kb | Distal (>10kb) Multiome | 969 | |
| chr1:26,177,126–26,177,750 | 179.3 kb | Distal (>10kb) Multiome | 363 | |
| chr1:26,200,994–26,201,612 | 203.1 kb | Distal (>10kb) Multiome | 369 | |
| chr1:26,225,042–26,225,908 | 227.3 kb | Distal (>10kb) Multiome | 462 | |
| chr1:26,233,613–26,234,924 | 236.0 kb | Distal (>10kb) Multiome | 867 | |
| chr1:26,275,604–26,276,096 | 277.7 kb | Distal (>10kb) Multiome | 373 | |
| chr1:26,279,438–26,280,566 | 281.9 kb | Distal (>10kb) Multiome | 820 |
Genomic view of the PAFAH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.