This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for STMN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STMN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STMN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:25,615,967–25,618,316 | 289.8 kb | Distal (>10kb) Multiome | 585 | |
| chr1:25,707,237–25,707,853 | 199.0 kb | Distal (>10kb) Multiome | 136 | |
| chr1:25,799,785–25,800,844 | 106.3 kb | Distal (>10kb) Multiome | 369 | |
| chr1:25,819,447–25,821,126 | 86.4 kb | Distal (>10kb) Multiome | 904 | |
| chr1:25,831,516–25,832,168 | 74.5 kb | Distal (>10kb) Multiome | 89 | |
| chr1:25,847,840–25,848,970 | 57.8 kb | Distal (>10kb) Multiome | 94 | |
| chr1:25,858,921–25,859,851 | 47.0 kb | Distal (>10kb) Multiome | 881 | |
| chr1:25,874,962–25,876,490 | 30.8 kb | Distal (>10kb) Multiome | 888 | |
| chr1:25,895,422–25,895,979 | 10.8 kb | Distal (>10kb) Multiome | 500 | |
| chr1:25,905,055–25,907,219 | 833 bp | At TSS Multiome | 917 | |
| chr1:25,922,512–25,923,426 | 16.4 kb | Distal (>10kb) Multiome | 386 | |
| chr1:25,968,758–25,969,159 | 62.5 kb | Distal (>10kb) Multiome | 17 | |
| chr1:25,997,628–25,998,708 | 91.8 kb | Distal (>10kb) Multiome HiCAR | 1091 | |
| chr1:26,021,572–26,022,167 | 115.3 kb | Distal (>10kb) Multiome | 231 | |
| chr1:26,034,958–26,036,424 | 129.7 kb | Distal (>10kb) Multiome | 780 | |
| chr1:26,045,386–26,046,127 | 139.5 kb | Distal (>10kb) Multiome | 178 | |
| chr1:26,093,947–26,095,162 | 187.8 kb | Distal (>10kb) Multiome | 403 | |
| chr1:26,110,626–26,112,596 | 205.4 kb | Distal (>10kb) Multiome | 934 | |
| chr1:26,161,287–26,162,232 | 255.4 kb | Distal (>10kb) Multiome | 564 | |
| chr1:26,164,134–26,165,044 | 258.1 kb | Distal (>10kb) Multiome | 500 | |
| chr1:26,169,358–26,170,373 | 263.5 kb | Distal (>10kb) Multiome | 969 | |
| chr1:26,177,126–26,177,750 | 271.0 kb | Distal (>10kb) Multiome | 363 | |
| chr1:26,200,994–26,201,612 | 294.8 kb | Distal (>10kb) Multiome | 369 |
Genomic view of the STMN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.