ATF3
activating transcription factor 3

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]

Developmental clusters: GC2
Biological processes 49 terms
CHOP-ATF3 complex (GO:1990622)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)cellular response to amino acid starvation (GO:0034198)chromatin (GO:0000785)endoplasmic reticulum unfolded protein response (GO:0030968)identical protein binding (GO:0042802)negative regulation of ERK1 and ERK2 cascade (GO:0070373)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of TRAIL-activated apoptotic signaling pathway (GO:1903984)positive regulation of cell population proliferation (GO:0008284)positive regulation of gene expression (GO:0010628)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to endoplasmic reticulum stress (GO:0034976)sequence-specific double-stranded DNA binding (GO:1990837)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)
Expression (TPM)
ATF3 — as a Regulated Gene

TFs regulating ATF3 0 TFs

Transcription factors with Perturb-seq knockdown data for ATF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ATF3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:212,309,881–212,310,794 298.4 kb Distal (>10kb) Multiome 183
chr1:212,315,914–212,316,445 292.5 kb Distal (>10kb) Multiome 140
chr1:212,413,972–212,416,004 193.7 kb Distal (>10kb) Multiome 833
chr1:212,432,597–212,433,702 175.7 kb Distal (>10kb) Multiome 576
chr1:212,477,008–212,477,651 131.3 kb Distal (>10kb) Multiome 419
chr1:212,498,151–212,499,452 109.8 kb Distal (>10kb) Multiome 216
chr1:212,514,035–212,515,926 93.2 kb Distal (>10kb) Multiome 524
chr1:212,558,067–212,559,384 49.7 kb Distal (>10kb) Multiome 891
chr1:212,605,830–212,610,097 1.0 kb Proximal (<10kb) Multiome 1097
chr1:212,629,910–212,630,849 21.6 kb Distal (>10kb) Multiome 331
chr1:212,665,118–212,665,789 56.9 kb Distal (>10kb) Multiome 678
chr1:212,698,874–212,700,500 90.7 kb Distal (>10kb) Multiome 710
chr1:212,791,461–212,792,424 183.2 kb Distal (>10kb) Multiome 1108
chr1:212,857,574–212,859,115 249.5 kb Distal (>10kb) Multiome 946
chr1:212,860,779–212,861,295 252.3 kb Distal (>10kb) Multiome 315
chr1:212,907,964–212,908,918 299.7 kb Distal (>10kb) Multiome 62

Genome Browser

Genomic view of the ATF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:212,299,881 – 212,918,918
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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