This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IRF2BP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IRF2BP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IRF2BP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:234,372,993–234,374,088 | 236.7 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:234,478,073–234,479,488 | 131.2 kb | Distal (>10kb) Multiome | 772 | |
| chr1:234,490,875–234,491,564 | 119.0 kb | Distal (>10kb) Multiome | 380 | |
| chr1:234,599,730–234,600,673 | 10.1 kb | Distal (>10kb) Multiome | 1062 | |
| chr1:234,608,182–234,611,760 | 123 bp | At TSS Multiome | 1183 | |
| chr1:234,724,044–234,724,506 | 114.1 kb | Distal (>10kb) Multiome HiCAR | 1023 | |
| chr1:234,750,669–234,751,976 | 141.2 kb | Distal (>10kb) Multiome | 369 | |
| chr1:235,093,150–235,094,131 | 483.6 kb | Distal (>10kb) Multiome HiCAR | 491 |
Genomic view of the IRF2BP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.