This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for DAXX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DAXX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DAXX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:33,080,635–33,081,087 | 242.3 kb | Distal (>10kb) Multiome | 141 | |
| chr6:33,161,505–33,162,100 | 161.3 kb | Distal (>10kb) Multiome | 589 | |
| chr6:33,199,801–33,201,289 | 122.3 kb | Distal (>10kb) Multiome | 1049 | |
| chr6:33,204,263–33,205,422 | 118.3 kb | Distal (>10kb) Multiome | 762 | |
| chr6:33,208,069–33,208,990 | 114.4 kb | Distal (>10kb) Multiome | 858 | |
| chr6:33,248,132–33,249,983 | 74.7 kb | Distal (>10kb) Multiome | 961 | |
| chr6:33,271,370–33,272,508 | 51.0 kb | Distal (>10kb) Multiome | 1058 | |
| chr6:33,276,685–33,277,905 | 45.5 kb | Distal (>10kb) Multiome | 807 | |
| chr6:33,288,941–33,289,881 | 33.6 kb | Distal (>10kb) Multiome | 701 | |
| chr6:33,297,445–33,300,232 | 25.1 kb | Distal (>10kb) Multiome | 1095 | |
| chr6:33,312,436–33,314,207 | 10.1 kb | Distal (>10kb) Multiome | 795 | |
| chr6:33,314,948–33,315,286 | 7.7 kb | Proximal (<10kb) | 249 | |
| chr6:33,317,189–33,318,504 | 5.0 kb | Proximal (<10kb) Multiome | 649 | |
| chr6:33,322,636–33,323,832 | 179 bp | At TSS Multiome | 941 | |
| chr6:33,346,609–33,347,126 | 23.8 kb | Distal (>10kb) Multiome | 37 | |
| chr6:33,390,888–33,392,247 | 68.7 kb | Distal (>10kb) Multiome | 993 | |
| chr6:33,409,936–33,411,502 | 87.5 kb | Distal (>10kb) Multiome | 977 | |
| chr6:33,417,606–33,419,249 | 95.3 kb | Distal (>10kb) Multiome | 973 | |
| chr6:33,419,793–33,420,532 | 97.2 kb | Distal (>10kb) Multiome | 162 | |
| chr6:33,425,590–33,426,362 | 102.9 kb | Distal (>10kb) Multiome | 665 | |
| chr6:33,431,024–33,432,096 | 108.2 kb | Distal (>10kb) Multiome | 337 | |
| chr6:33,454,074–33,454,852 | 131.5 kb | Distal (>10kb) Multiome | 906 | |
| chr6:33,547,185–33,548,324 | 224.7 kb | Distal (>10kb) Multiome | 155 | |
| chr6:33,570,899–33,571,638 | 248.4 kb | Distal (>10kb) Multiome | 755 | |
| chr6:33,579,935–33,580,700 | 257.3 kb | Distal (>10kb) Multiome | 639 | |
| chr6:33,592,764–33,593,449 | 270.0 kb | Distal (>10kb) Multiome | 224 | |
| chr6:33,620,828–33,622,474 | 299.1 kb | Distal (>10kb) Multiome | 594 |
Genomic view of the DAXX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.