Enables damaged DNA binding activity. Involved in double-strand break repair via homologous recombination; negative regulation of double-strand break repair via nonhomologous end joining; and spindle organization. Located in centrosome; site of DNA damage; and spindle pole. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AUNIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AUNIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AUNIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:25,615,967–25,618,316 | 242.9 kb | Distal (>10kb) Multiome | 585 | |
| chr1:25,707,237–25,707,853 | 152.1 kb | Distal (>10kb) Multiome | 136 | |
| chr1:25,799,785–25,800,844 | 59.3 kb | Distal (>10kb) Multiome | 369 | |
| chr1:25,819,447–25,821,126 | 39.5 kb | Distal (>10kb) Multiome | 904 | |
| chr1:25,831,516–25,832,168 | 27.6 kb | Distal (>10kb) Multiome | 89 | |
| chr1:25,847,840–25,848,970 | 10.9 kb | Distal (>10kb) Multiome | 94 | |
| chr1:25,858,921–25,859,851 | 5 bp | At TSS Multiome | 881 | |
| chr1:25,874,962–25,876,490 | 16.2 kb | Distal (>10kb) Multiome | 888 | |
| chr1:25,895,422–25,895,979 | 36.1 kb | Distal (>10kb) Multiome | 500 | |
| chr1:25,905,055–25,907,219 | 46.1 kb | Distal (>10kb) Multiome | 917 | |
| chr1:25,922,512–25,923,426 | 63.4 kb | Distal (>10kb) Multiome | 386 | |
| chr1:25,968,758–25,969,159 | 109.5 kb | Distal (>10kb) Multiome | 17 | |
| chr1:25,997,628–25,998,708 | 138.8 kb | Distal (>10kb) Multiome | 1091 | |
| chr1:26,021,572–26,022,167 | 162.3 kb | Distal (>10kb) Multiome | 231 | |
| chr1:26,034,958–26,036,424 | 176.7 kb | Distal (>10kb) Multiome | 780 | |
| chr1:26,045,386–26,046,127 | 186.5 kb | Distal (>10kb) Multiome | 178 | |
| chr1:26,093,947–26,095,162 | 234.8 kb | Distal (>10kb) Multiome | 403 | |
| chr1:26,110,626–26,112,596 | 252.4 kb | Distal (>10kb) Multiome | 934 |
Genomic view of the AUNIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.