This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for REL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:60,581,429–60,582,120 | 299.6 kb | Distal (>10kb) Multiome | 468 | |
| chr2:60,674,358–60,675,116 | 206.8 kb | Distal (>10kb) Multiome | 335 | |
| chr2:60,735,617–60,736,154 | 145.6 kb | Distal (>10kb) Multiome | 172 | |
| chr2:60,756,026–60,757,043 | 125.2 kb | Distal (>10kb) Multiome | 703 | |
| chr2:60,853,117–60,853,733 | 28.1 kb | Distal (>10kb) Multiome | 48 | |
| chr2:60,880,748–60,882,118 | 36 bp | At TSS Multiome | 991 | |
| chr2:61,016,845–61,018,378 | 135.9 kb | Distal (>10kb) Multiome | 1133 | |
| chr2:61,065,384–61,066,693 | 184.3 kb | Distal (>10kb) Multiome | 856 | |
| chr2:61,144,728–61,145,208 | 263.5 kb | Distal (>10kb) Multiome | 512 | |
| chr2:61,157,943–61,158,813 | 277.0 kb | Distal (>10kb) Multiome | 49 | |
| chr2:61,165,843–61,166,373 | 284.6 kb | Distal (>10kb) Multiome | 88 | |
| chr2:61,176,826–61,178,378 | 295.8 kb | Distal (>10kb) Multiome | 1042 |
Genomic view of the REL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.