Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF30. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF30 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF30, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:34,668,047–34,668,472 | 258.4 kb | Distal (>10kb) Multiome | 24 | |
| chr19:34,676,923–34,678,053 | 249.3 kb | Distal (>10kb) Multiome | 728 | |
| chr19:34,733,416–34,734,655 | 192.7 kb | Distal (>10kb) Multiome | 1008 | |
| chr19:34,772,709–34,773,413 | 153.7 kb | Distal (>10kb) Multiome | 680 | |
| chr19:34,920,040–34,921,057 | 6.4 kb | Proximal (<10kb) Multiome | 309 | |
| chr19:34,926,731–34,927,343 | 63 bp | At TSS Multiome | 741 | |
| chr19:34,963,909–34,964,414 | 37.3 kb | Distal (>10kb) Multiome | 645 | |
| chr19:34,999,304–35,000,970 | 73.3 kb | Distal (>10kb) Multiome | 759 | |
| chr19:35,030,124–35,031,270 | 103.6 kb | Distal (>10kb) Multiome | 534 | |
| chr19:35,040,969–35,041,953 | 114.7 kb | Distal (>10kb) Multiome | 806 | |
| chr19:35,055,754–35,056,570 | 129.1 kb | Distal (>10kb) Multiome | 268 | |
| chr19:35,066,952–35,067,448 | 140.3 kb | Distal (>10kb) Multiome | 497 | |
| chr19:35,067,923–35,068,779 | 141.8 kb | Distal (>10kb) Multiome | 190 | |
| chr19:35,090,562–35,091,150 | 163.9 kb | Distal (>10kb) Multiome | 303 | |
| chr19:35,135,242–35,135,695 | 208.6 kb | Distal (>10kb) Multiome | 525 | |
| chr19:35,140,763–35,141,948 | 214.5 kb | Distal (>10kb) Multiome | 509 | |
| chr19:35,142,085–35,143,541 | 216.1 kb | Distal (>10kb) Multiome | 328 | |
| chr19:35,154,641–35,155,298 | 228.2 kb | Distal (>10kb) Multiome | 552 |
Genomic view of the ZNF30 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.