Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in ERAD pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAN1C1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAN1C1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAN1C1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:25,338,116–25,338,949 | 278.3 kb | Distal (>10kb) Multiome | 803 | |
| chr1:25,429,935–25,431,604 | 186.5 kb | Distal (>10kb) Multiome | 845 | |
| chr1:25,543,218–25,544,436 | 73.1 kb | Distal (>10kb) Multiome | 569 | |
| chr1:25,608,663–25,608,872 | 7.9 kb | Proximal (<10kb) | 215 | |
| chr1:25,615,967–25,618,316 | 192 bp | At TSS Multiome | 585 | |
| chr1:25,618,991–25,619,356 | 2.2 kb | Proximal (<10kb) | 152 | |
| chr1:25,707,237–25,707,853 | 90.6 kb | Distal (>10kb) Multiome | 136 | |
| chr1:25,799,785–25,800,844 | 183.4 kb | Distal (>10kb) Multiome HiCAR | 369 | |
| chr1:25,819,447–25,821,126 | 203.2 kb | Distal (>10kb) Multiome | 904 | |
| chr1:25,831,516–25,832,168 | 215.1 kb | Distal (>10kb) Multiome | 89 | |
| chr1:25,847,840–25,848,970 | 231.8 kb | Distal (>10kb) Multiome | 94 | |
| chr1:25,858,921–25,859,851 | 242.7 kb | Distal (>10kb) Multiome | 881 | |
| chr1:25,874,962–25,876,490 | 258.8 kb | Distal (>10kb) Multiome | 888 | |
| chr1:25,895,422–25,895,979 | 278.8 kb | Distal (>10kb) Multiome | 500 | |
| chr1:25,905,055–25,907,219 | 288.8 kb | Distal (>10kb) Multiome | 917 |
Genomic view of the MAN1C1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.