Predicted to enable protein kinase activity. Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of G2/MI transition of meiotic cell cycle. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PDIK1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDIK1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDIK1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:25,819,447–25,821,126 | 291.8 kb | Distal (>10kb) Multiome | 904 | |
| chr1:25,831,516–25,832,168 | 279.9 kb | Distal (>10kb) Multiome | 89 | |
| chr1:25,847,840–25,848,970 | 263.2 kb | Distal (>10kb) Multiome | 94 | |
| chr1:25,858,921–25,859,851 | 252.4 kb | Distal (>10kb) Multiome | 881 | |
| chr1:25,874,962–25,876,490 | 236.2 kb | Distal (>10kb) Multiome | 888 | |
| chr1:25,895,422–25,895,979 | 216.2 kb | Distal (>10kb) Multiome | 500 | |
| chr1:25,905,055–25,907,219 | 206.2 kb | Distal (>10kb) Multiome | 917 | |
| chr1:25,922,512–25,923,426 | 189.0 kb | Distal (>10kb) Multiome | 386 | |
| chr1:25,968,758–25,969,159 | 142.9 kb | Distal (>10kb) Multiome | 17 | |
| chr1:25,997,628–25,998,708 | 113.6 kb | Distal (>10kb) Multiome | 1091 | |
| chr1:26,021,572–26,022,167 | 90.1 kb | Distal (>10kb) Multiome | 231 | |
| chr1:26,034,958–26,036,424 | 75.7 kb | Distal (>10kb) Multiome | 780 | |
| chr1:26,045,386–26,046,127 | 65.9 kb | Distal (>10kb) Multiome | 178 | |
| chr1:26,093,947–26,095,162 | 17.6 kb | Distal (>10kb) Multiome | 403 | |
| chr1:26,110,626–26,112,596 | 14 bp | At TSS Multiome | 934 | |
| chr1:26,161,287–26,162,232 | 50.0 kb | Distal (>10kb) Multiome | 564 | |
| chr1:26,164,134–26,165,044 | 52.7 kb | Distal (>10kb) Multiome | 500 | |
| chr1:26,169,358–26,170,373 | 58.1 kb | Distal (>10kb) Multiome | 969 | |
| chr1:26,177,126–26,177,750 | 65.6 kb | Distal (>10kb) Multiome | 363 | |
| chr1:26,200,994–26,201,612 | 89.4 kb | Distal (>10kb) Multiome | 369 | |
| chr1:26,225,042–26,225,908 | 113.6 kb | Distal (>10kb) Multiome | 462 | |
| chr1:26,233,613–26,234,924 | 122.3 kb | Distal (>10kb) Multiome | 867 | |
| chr1:26,275,604–26,276,096 | 164.0 kb | Distal (>10kb) Multiome | 373 | |
| chr1:26,279,438–26,280,566 | 168.2 kb | Distal (>10kb) Multiome | 820 | |
| chr1:26,306,331–26,306,935 | 194.9 kb | Distal (>10kb) Multiome | 563 | |
| chr1:26,335,993–26,337,256 | 224.7 kb | Distal (>10kb) Multiome | 655 | |
| chr1:26,360,031–26,360,668 | 248.5 kb | Distal (>10kb) Multiome | 164 | |
| chr1:26,409,125–26,412,949 | 298.7 kb | Distal (>10kb) Multiome | 517 |
Genomic view of the PDIK1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.