LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for LCOR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LCOR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LCOR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:96,586,308–96,587,486 | 245.2 kb | Distal (>10kb) Multiome | 840 | |
| chr10:96,719,871–96,720,167 | 112.2 kb | Distal (>10kb) Multiome | 395 | |
| chr10:96,720,285–96,721,494 | 111.4 kb | Distal (>10kb) Multiome | 522 | |
| chr10:96,830,640–96,831,120 | 1.1 kb | Proximal (<10kb) | 213 | |
| chr10:96,831,710–96,834,047 | 212 bp | At TSS Multiome | 859 | |
| chr10:97,037,342–97,037,879 | 205.3 kb | Distal (>10kb) Multiome | 469 | |
| chr10:97,089,264–97,089,736 | 257.2 kb | Distal (>10kb) Multiome | 49 |
Genomic view of the LCOR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.