The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for ZEB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZEB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZEB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:144,331,548–144,333,361 | 183.7 kb | Distal (>10kb) Multiome | 956 | |
| chr2:144,443,951–144,446,058 | 70.8 kb | Distal (>10kb) Multiome | 395 | |
| chr2:144,509,159–144,509,372 | 8.0 kb | Proximal (<10kb) | 88 | |
| chr2:144,510,248–144,511,014 | 6.4 kb | Proximal (<10kb) | 341 | |
| chr2:144,515,704–144,517,815 | at TSS | At TSS | 544 | |
| chr2:144,520,037–144,520,397 | 2.6 kb | Proximal (<10kb) | 425 | |
| chr2:144,522,700–144,524,831 | 8.2 kb | Proximal (<10kb) Multiome | 591 | |
| chr2:145,798,267–145,799,205 | 1282.5 kb | Distal (>10kb) Multiome HiCAR | 81 |
Genomic view of the ZEB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.