This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Transcription factors with Perturb-seq knockdown data for FEZF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FEZF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FEZF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:122,143,073–122,145,002 | 160.3 kb | Distal (>10kb) Multiome | 722 | |
| chr7:122,299,579–122,300,851 | 4.4 kb | Proximal (<10kb) Multiome | 245 | |
| chr7:122,301,809–122,302,300 | 2.2 kb | Proximal (<10kb) | 172 | |
| chr7:122,303,627–122,307,580 | 194 bp | At TSS Multiome | 581 | |
| chr7:122,308,994–122,309,828 | 4.5 kb | Proximal (<10kb) | 54 | |
| chr7:122,310,121–122,311,074 | 6.2 kb | Proximal (<10kb) Multiome | 257 | |
| chr7:122,311,162–122,311,613 | 6.7 kb | Proximal (<10kb) | 71 | |
| chr7:122,311,746–122,312,170 | 7.2 kb | Proximal (<10kb) | 131 | |
| chr7:122,314,863–122,315,905 | 4.2 kb | Proximal (<10kb) | 134 | |
| chr7:122,316,043–122,317,455 | 12.5 kb | Distal (>10kb) Multiome | 288 | |
| chr7:122,328,635–122,329,533 | 24.8 kb | Distal (>10kb) Multiome | 148 | |
| chr7:122,438,074–122,438,817 | 133.9 kb | Distal (>10kb) Multiome | 200 |
Genomic view of the FEZF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.