chr10 : 6,128,815 6,129,204
389 bp 94 TFs 0 linked genes
This 389 bp open chromatin element has no linked target genes and is bound by 94 transcription factors.
Linked Genes
No linked genes
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr10:6,123,815 – 6,134,204
This element Other elements ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
94 transcription factors
Source
Cell type
AHR 1 dataset
ChIP MCF-7_TCDD_45min GSE90550.AHR.MCF-7_TCDD_45min 137 bp overlap
AR 1 dataset
ChIP THP-1_R1881 GSE131381.AR.THP-1_R1881 170 bp overlap
BCOR 2 datasets
ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 224 bp overlap
ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 239 bp overlap
BRD2 1 dataset
ChIP K-562 GSE140325.BRD2.K-562 107 bp overlap
BRD4 4 datasets
ChIP MV4-11-B_BI00894999_100nM_4h GSE101821.BRD4.MV4-11-B_BI00894999_100nM_4h 389 bp overlap
ChIP MV4-11-B_BI00894999_35nM_4h GSE101821.BRD4.MV4-11-B_BI00894999_35nM_4h 334 bp overlap
ChIP MV4-11-B_DMSO GSE101821.BRD4.MV4-11-B_DMSO 285 bp overlap
ChIP MV4-11_SGC GSE71776.BRD4.MV4-11_SGC 255 bp overlap
CBFA2T3 1 dataset
ChIP Kasumi-1 GSE126953.CBFA2T3.Kasumi-1 127 bp overlap
CDKN1B 1 dataset
ChIP MDA-MB-231_p27CK-DD GSE112444.CDKN1B.MDA-MB-231_p27CK-DD 245 bp overlap
CEBPA 1 dataset
ChIP SKH1_10d GSE87283.CEBPA.SKH1_10d 168 bp overlap
CHD7 1 dataset
ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 197 bp overlap
CREBBP 1 dataset
ChIP monocyte_LPS GSE131294.CREBBP.monocyte_LPS 165 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF335XTP 251 bp overlap
E2F7 1 dataset
ChIP IMR-90_QUIES GSE40343.E2F7.IMR-90_QUIES 111 bp overlap
EED 1 dataset
ChIP ProEs GSE59087.EED.ProEs 242 bp overlap
ELF1 1 dataset
ChIP K-562 ENCSR000BMD.ELF1.K-562 109 bp overlap
EMSY 1 dataset
ChIP K562 ENCFF511ZZZ 220 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 284 bp overlap
EP300 4 datasets
ChIP AML GSE131939.EP300.AML 187 bp overlap
ChIP AML_shaml1-eto GSE131939.EP300.AML_shaml1-eto 199 bp overlap
ChIP Kasumi-1 GSE115115.EP300.Kasumi-1 187 bp overlap
ChIP pulmonary-artery_endothelial-cell_siPFKFB3 GSE89786.EP300.pulmonary-artery_endothelial-cell_siPFKFB3 218 bp overlap
ERG 2 datasets
ChIP ME-1 GSE46044.ERG.ME-1 321 bp overlap
ChIP SKNO-1 GSE23730.ERG.SKNO-1 200 bp overlap
ESR1 4 datasets
ChIP MCF-7 GSE94023.ESR1.MCF-7 181 bp overlap
ChIP MCF-7_E2+4OHT_SRC-3 GSE119702.ESR1.MCF-7_E2+4OHT_SRC-3 181 bp overlap
ChIP MCF-7_R5020 GSE68355.ESR1.MCF-7_R5020 336 bp overlap
ChIP MCF-7_SRC3_OHT GSE119702.ESR1.MCF-7_SRC3_OHT 181 bp overlap
ETS1 2 datasets
ChIP HUVEC-C_VEGF_12H GSE41166.ETS1.HUVEC-C_VEGF_12H 168 bp overlap
ChIP HUVEC-C_VEGF_4H GSE41166.ETS1.HUVEC-C_VEGF_4H 186 bp overlap
EVI1 2 datasets
ChIP SKH1 GSE87283.EVI1.SKH1 365 bp overlap
ChIP SKH1_10d GSE87283.EVI1.SKH1_10d 155 bp overlap
EZH2 1 dataset
ChIP LNCaP-abl GSE39459.EZH2.LNCaP-abl 138 bp overlap
FLI1 1 dataset
ChIP HUVEC-C GSE109695.FLI1.HUVEC-C 205 bp overlap
FOS 3 datasets
ChIP MCF-7 ENCFF282FWZ 294 bp overlap
ChIP MCF-7 ENCSR569XNP.FOS.MCF-7 282 bp overlap
ChIP endothelial_umbilical-vein ENCSR000EVU.FOS.endothelial_umbilical-vein 220 bp overlap
FOXA1 1 dataset
ChIP MCF-7_JC4690 GSE126004.FOXA1.MCF-7_JC4690 185 bp overlap
FOXL2 1 dataset
ChIP KGN_1513 GSE138496.FOXL2.KGN_1513 181 bp overlap
FOXO1 1 dataset
ChIP CD34 GSE80773.FOXO1.CD34 186 bp overlap
GATA1 1 dataset
ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 138 bp overlap
GATA2 4 datasets
ChIP ME-1_CBFB-MYH11-KD GSE117138.GATA2.ME-1_CBFB-MYH11-KD 171 bp overlap
ChIP SKH1 GSE87283.GATA2.SKH1 389 bp overlap
ChIP primary-endometrial-stromal-cell_IVD_P1 GSE145673.GATA2.primary-endometrial-stromal-cell_IVD_P1 209 bp overlap
ChIP primary-endometrial-stromal-cell_IVD_P2 GSE145673.GATA2.primary-endometrial-stromal-cell_IVD_P2 163 bp overlap
GATA3 1 dataset
ChIP MCF-7 GSE122847.GATA3.MCF-7 133 bp overlap
GATA4 1 dataset
ChIP BJ1-hTERT GSE92491.GATA4.BJ1-hTERT 139 bp overlap
GATA6 5 datasets
ChIP DE_D1 S09-DE-d1-GATA6-exp1 219 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 145 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 265 bp overlap
ChIP OACP4-C GSE132680.GATA6.OACP4-C 127 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 185 bp overlap
GRHL2 3 datasets
ChIP HBE GSE46194.GRHL2.HBE 199 bp overlap
ChIP OVCA429 GSE71018.GRHL2.OVCA429 195 bp overlap
ChIP T-47D GSE99680.GRHL2.T-47D 226 bp overlap
HOXB8 1 dataset
ChIP K-562 GSE121208.HOXB8.K-562 195 bp overlap
IKZF1 4 datasets
ChIP BCR-ABL1 GSE58825.IKZF1.BCR-ABL1 164 bp overlap
ChIP BCR-ABL1_LAX2 GSE58825.IKZF1.BCR-ABL1_LAX2 373 bp overlap
ChIP K-562 ENCSR395HWC.IKZF1.K-562 389 bp overlap
ChIP K562 ENCFF348IBL 356 bp overlap
ILF3 1 dataset
ChIP K-562 GSE103215.ILF3.K-562 84 bp overlap
JUN 4 datasets
ChIP DE_D1 S40-DE-d1-JUN-exp2 284 bp overlap
ChIP HAEC_IL1b_4h GSE89970.JUN.HAEC_IL1b_4h 129 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 312 bp overlap
ChIP MDA-BoM-1833 GSE112444.JUN.MDA-BoM-1833 184 bp overlap
JUND 2 datasets
ChIP K-562 ENCSR000EGN.JUND.K-562 143 bp overlap
ChIP Kasumi-1_ctrl GSE117105.JUND.Kasumi-1_ctrl 147 bp overlap
KDM1A 2 datasets
ChIP K562 ENCFF934ZRG 333 bp overlap
ChIP keratinocyte_diff GSE57702.KDM1A.keratinocyte_diff 157 bp overlap
KLF4 1 dataset
ChIP keratinocyte_diff GSE57702.KLF4.keratinocyte_diff 209 bp overlap
KMT2A 1 dataset
ChIP L826 GSE83671.KMT2A.L826 306 bp overlap
LDB1 2 datasets
ChIP Kasumi-1_ctrl GSE121280.LDB1.Kasumi-1_ctrl 380 bp overlap
ChIP Kasumi-1_siRE GSE121280.LDB1.Kasumi-1_siRE 340 bp overlap
LMO2 2 datasets
ChIP Kasumi-1_SICTR GSE60130.LMO2.Kasumi-1_SICTR 275 bp overlap
ChIP Kasumi-1_SIRUNX1ETO GSE60130.LMO2.Kasumi-1_SIRUNX1ETO 259 bp overlap
MAF 1 dataset
ChIP keratinocyte_epidermal_PROLIF GSE52953.MAF.keratinocyte_epidermal_PROLIF 183 bp overlap
MAFB 1 dataset
ChIP islet ERP004003.MAFB.islet 168 bp overlap
MAFF 4 datasets
ChIP HeLa-S3 ENCSR140DSL.MAFF.HeLa-S3 64 bp overlap
ChIP HepG2 ENCFF452YUT 143 bp overlap
ChIP K-562 ENCSR000EGI.MAFF.K-562 168 bp overlap
ChIP K562 ENCFF071YKK 180 bp overlap
MAFG 2 datasets
ChIP K-562 ENCSR818DQV.MAFG.K-562 345 bp overlap
ChIP K562 ENCFF455EEO 162 bp overlap
MAFK 9 datasets
ChIP A549 ENCFF371EPR 66 bp overlap
ChIP Hep-G2 ENCSR000EDZ.MAFK.Hep-G2 117 bp overlap
ChIP HepG2 ENCFF743ZOF 131 bp overlap
ChIP HepG2 ENCFF767LDG 138 bp overlap
ChIP IMR-90 ENCFF336DHZ 69 bp overlap
ChIP K-562 ENCSR000EGX.MAFK.K-562 129 bp overlap
ChIP K562 ENCFF380WHM 162 bp overlap
ChIP MCF-7 ENCFF558JLG 276 bp overlap
ChIP MCF-7 ENCSR555PBN.MAFK.MCF-7 211 bp overlap
MAML1 1 dataset
ChIP SCC_4h GSE156486.MAML1.SCC_4h 189 bp overlap
MAZ 2 datasets
ChIP IMR-90 ENCFF682IKN 268 bp overlap
ChIP IMR-90 ENCSR000EFF.MAZ.IMR-90 179 bp overlap
MECOM 1 dataset
ChIP SKH1_CEBPA-ER_E2 GSE102697.MECOM.SKH1_CEBPA-ER_E2 173 bp overlap
MED1 1 dataset
ChIP U-87MG GSE36354.MED1.U-87MG 184 bp overlap
MED12 1 dataset
ChIP myometrium_PT916 GSE128230.MED12.myometrium_PT916 67 bp overlap
MEIS2 1 dataset
ChIP K-562 ENCSR851BNE.MEIS2.K-562 180 bp overlap
MYBL2 1 dataset
ChIP A-673 GSE119971.MYBL2.A-673 202 bp overlap
NCAPH2 1 dataset
ChIP IMR-90_Triptolide-5min GSE118494.NCAPH2.IMR-90_Triptolide-5min 301 bp overlap
NCOR2 1 dataset
ChIP AML_shaml1-eto GSE131939.NCOR2.AML_shaml1-eto 161 bp overlap
NEUROG2 4 datasets
ChIP MRC-5_NFD_02DPT GSE75910.NEUROG2.MRC-5_NFD_02DPT 231 bp overlap
ChIP MRC-5_NFD_05DPT GSE75910.NEUROG2.MRC-5_NFD_05DPT 187 bp overlap
ChIP MRC-5_NFD_1DPT GSE75910.NEUROG2.MRC-5_NFD_1DPT 282 bp overlap
ChIP MRC-5_N_05DPT GSE75910.NEUROG2.MRC-5_N_05DPT 224 bp overlap
NR3C1 1 dataset
ChIP ALL_DEX GSE109946.NR3C1.ALL_DEX 263 bp overlap
NRF1 1 dataset
ChIP T-47D_HAEGIN2 GSE59935.NRF1.T-47D_HAEGIN2 158 bp overlap
OTX2 1 dataset
ChIP retina_pigment GSE60024.OTX2.retina_pigment 166 bp overlap
PAX3-FOXO1 1 dataset
ChIP Hs-352-Sk_PAX3-FOXO1-vector GSE83725.PAX3-FOXO1.Hs-352-Sk_PAX3-FOXO1-vector 78 bp overlap
PGR 1 dataset
ChIP myometrium_NP1 GSE137550.PGR.myometrium_NP1 254 bp overlap
POLR2A 5 datasets
ChIP adrenal gland ENCFF843OBJ 389 bp overlap
ChIP esophagus muscularis mucosa ENCFF759BBR 326 bp overlap
ChIP spleen ENCFF044PYR 347 bp overlap
ChIP spleen ENCFF446ZGT 337 bp overlap
ChIP upper lobe of left lung ENCFF199JUI 256 bp overlap
RAD21 1 dataset
ChIP THP-1_eGFP-IFNb GSE103477.RAD21.THP-1_eGFP-IFNb 219 bp overlap
RCOR1 1 dataset
ChIP keratinocyte_diff GSE57702.RCOR1.keratinocyte_diff 241 bp overlap
RELA 22 datasets
ChIP aortic-endothelial-cell_IL1B_D10 GSE139377.RELA.aortic-endothelial-cell_IL1B_D10 258 bp overlap
ChIP aortic-endothelial-cell_IL1B_D11 GSE139377.RELA.aortic-endothelial-cell_IL1B_D11 314 bp overlap
ChIP aortic-endothelial-cell_IL1B_D13 GSE139377.RELA.aortic-endothelial-cell_IL1B_D13 347 bp overlap
ChIP aortic-endothelial-cell_IL1B_D14 GSE139377.RELA.aortic-endothelial-cell_IL1B_D14 298 bp overlap
ChIP aortic-endothelial-cell_IL1B_D16 GSE139377.RELA.aortic-endothelial-cell_IL1B_D16 297 bp overlap
ChIP aortic-endothelial-cell_IL1B_D2 GSE139377.RELA.aortic-endothelial-cell_IL1B_D2 357 bp overlap
ChIP aortic-endothelial-cell_IL1B_D21 GSE139377.RELA.aortic-endothelial-cell_IL1B_D21 366 bp overlap
ChIP aortic-endothelial-cell_IL1B_D22 GSE139377.RELA.aortic-endothelial-cell_IL1B_D22 213 bp overlap
ChIP aortic-endothelial-cell_IL1B_D26 GSE139377.RELA.aortic-endothelial-cell_IL1B_D26 385 bp overlap
ChIP aortic-endothelial-cell_IL1B_D33 GSE139377.RELA.aortic-endothelial-cell_IL1B_D33 279 bp overlap
ChIP aortic-endothelial-cell_IL1B_D38 GSE139377.RELA.aortic-endothelial-cell_IL1B_D38 322 bp overlap
ChIP aortic-endothelial-cell_IL1B_D39 GSE139377.RELA.aortic-endothelial-cell_IL1B_D39 278 bp overlap
ChIP aortic-endothelial-cell_IL1B_D4 GSE139377.RELA.aortic-endothelial-cell_IL1B_D4 223 bp overlap
ChIP aortic-endothelial-cell_IL1B_D40 GSE139377.RELA.aortic-endothelial-cell_IL1B_D40 340 bp overlap
ChIP aortic-endothelial-cell_IL1B_D41 GSE139377.RELA.aortic-endothelial-cell_IL1B_D41 280 bp overlap
ChIP aortic-endothelial-cell_IL1B_D47 GSE139377.RELA.aortic-endothelial-cell_IL1B_D47 207 bp overlap
ChIP aortic-endothelial-cell_IL1B_D49 GSE139377.RELA.aortic-endothelial-cell_IL1B_D49 168 bp overlap
ChIP aortic-endothelial-cell_IL1B_D53 GSE139377.RELA.aortic-endothelial-cell_IL1B_D53 181 bp overlap
ChIP aortic-endothelial-cell_IL1B_D6 GSE139377.RELA.aortic-endothelial-cell_IL1B_D6 179 bp overlap
ChIP aortic-endothelial-cell_IL1B_D7 GSE139377.RELA.aortic-endothelial-cell_IL1B_D7 284 bp overlap
ChIP aortic-endothelial-cell_IL1B_D8 GSE139377.RELA.aortic-endothelial-cell_IL1B_D8 389 bp overlap
ChIP aortic-endothelial-cell_IL1B_D9 GSE139377.RELA.aortic-endothelial-cell_IL1B_D9 387 bp overlap
RUNX1 12 datasets
ChIP AML_Blast GSE60130.RUNX1.AML_Blast 262 bp overlap
ChIP BCP-ALL_patient1 GSE109377.RUNX1.BCP-ALL_patient1 277 bp overlap
ChIP CD34 GSE64862.RUNX1.CD34 262 bp overlap
ChIP H9_DOX-5_HA GSE137670.RUNX1.H9_DOX-5_HA 178 bp overlap
ChIP Kasumi-1 GSE45738.RUNX1.Kasumi-1 355 bp overlap
ChIP Kasumi-1 GSE65427.RUNX1.Kasumi-1 126 bp overlap
ChIP ME-1 GSE117138.RUNX1.ME-1 244 bp overlap
ChIP ME-1_KD GSE128771.RUNX1.ME-1_KD 244 bp overlap
ChIP MV4-11 GSE79899.RUNX1.MV4-11 308 bp overlap
ChIP SKH1 GSE87283.RUNX1.SKH1 370 bp overlap
ChIP SKH1_10d GSE87283.RUNX1.SKH1_10d 239 bp overlap
ChIP SKH1_RUNX1-EVI1_KD GSE87283.RUNX1.SKH1_RUNX1-EVI1_KD 282 bp overlap
RUNX1T1 7 datasets
ChIP Kasumi-1 GSE115115.RUNX1T1.Kasumi-1 222 bp overlap
ChIP Kasumi-1 GSE102697.RUNX1T1.Kasumi-1 248 bp overlap
ChIP Kasumi-1 GSE43834.RUNX1T1.Kasumi-1 197 bp overlap
ChIP Kasumi-1 GSE65427.RUNX1T1.Kasumi-1 171 bp overlap
ChIP Kasumi-1_CEBPA-ER GSE102697.RUNX1T1.Kasumi-1_CEBPA-ER 257 bp overlap
ChIP Kasumi-1_CEBPA-ER_E2 GSE102697.RUNX1T1.Kasumi-1_CEBPA-ER_E2 157 bp overlap
ChIP Kasumi-1_E2 GSE102697.RUNX1T1.Kasumi-1_E2 174 bp overlap
SAP30 1 dataset
ChIP K562 ENCFF652WJB 389 bp overlap
SMAD3 1 dataset
ChIP BG03 GSE21614.SMAD3.BG03 142 bp overlap
SMC1 1 dataset
ChIP monocyte_IFNg-LPS GSE120943.SMC1.monocyte_IFNg-LPS 213 bp overlap
SPI1 8 datasets
ChIP DC_96h_donorM GSE128834.SPI1.DC_96h_donorM 260 bp overlap
ChIP K-562 ENCSR000BGW.SPI1.K-562 114 bp overlap
ChIP Kasumi-1_SICTR GSE60130.SPI1.Kasumi-1_SICTR 278 bp overlap
ChIP Kasumi-1_SIRUNX1ETO GSE60130.SPI1.Kasumi-1_SIRUNX1ETO 242 bp overlap
ChIP macrophage_D7_donorP GSE128834.SPI1.macrophage_D7_donorP 173 bp overlap
ChIP monocyte GSE31621.SPI1.monocyte 148 bp overlap
ChIP monocyte_MACROPHAGE GSE31621.SPI1.monocyte_MACROPHAGE 133 bp overlap
ChIP primary-monocyte_18h_donorO GSE128834.SPI1.primary-monocyte_18h_donorO 257 bp overlap
SREBP2 2 datasets
ChIP monocyte GSE129202.SREBP2.monocyte 389 bp overlap
ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 389 bp overlap
SS18-SSX 2 datasets
ChIP fibroblast_6aa GSE139053.SS18-SSX.fibroblast_6aa 187 bp overlap
ChIP fibroblast_78aa-SSX-Tail GSE139053.SS18-SSX.fibroblast_78aa-SSX-Tail 126 bp overlap
STAG2 1 dataset
ChIP HCAEC GSE101921.STAG2.HCAEC 185 bp overlap
STAT1 2 datasets
ChIP CD14_INFG_LPS GSE43036.STAT1.CD14_INFG_LPS 222 bp overlap
ChIP CD14_LPS GSE43036.STAT1.CD14_LPS 323 bp overlap
STAT3 7 datasets
ChIP MCF-7_jc5838 GSE126004.STAT3.MCF-7_jc5838 55 bp overlap
ChIP MCF-7_jc5848 GSE126004.STAT3.MCF-7_jc5848 237 bp overlap
ChIP MDA-MB-453 GSE152203.STAT3.MDA-MB-453 297 bp overlap
ChIP monocyte_IFNg GSE120943.STAT3.monocyte_IFNg 136 bp overlap
ChIP monocyte_IL10 GSE120943.STAT3.monocyte_IL10 201 bp overlap
ChIP monocyte_LPS GSE120943.STAT3.monocyte_LPS 255 bp overlap
ChIP monocyte_resting GSE120943.STAT3.monocyte_resting 212 bp overlap
STAT5A 1 dataset
ChIP MV4-11 GSE64862.STAT5A.MV4-11 145 bp overlap
SUZ12 2 datasets
ChIP ProEs GSE59087.SUZ12.ProEs 217 bp overlap
ChIP WA01 ENCSR000ATS.SUZ12.WA01 142 bp overlap
TAL1 1 dataset
ChIP TSU-1621MT GSE60477.TAL1.TSU-1621MT 296 bp overlap
TCF12 2 datasets
ChIP Kasumi-1 GSE23730.TCF12.Kasumi-1 186 bp overlap
ChIP Kasumi-1 GSE43834.TCF12.Kasumi-1 177 bp overlap
TCF21 1 dataset
ChIP HCASMC GSE124011.TCF21.HCASMC 97 bp overlap
TCF3 1 dataset
ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 389 bp overlap
TCF7L2 1 dataset
ChIP HepG2 ENCFF510OLG 332 bp overlap
TFAP4 1 dataset
ChIP Kasumi-1 GSE45738.TFAP4.Kasumi-1 350 bp overlap
TP63 3 datasets
ChIP keratinocyte_D0 GSE59824.TP63.keratinocyte_D0 165 bp overlap
ChIP keratinocyte_D2 GSE59824.TP63.keratinocyte_D2 263 bp overlap
ChIP keratinocyte_D7 GSE59824.TP63.keratinocyte_D7 124 bp overlap
UBTF 1 dataset
ChIP K-562 ENCSR000EFZ.UBTF.K-562 103 bp overlap
ZFP36 1 dataset
ChIP K-562 ENCSR776CYN.ZFP36.K-562 278 bp overlap
ZFP91 3 datasets
ChIP K-562 ENCSR898XMH.ZFP91.K-562 314 bp overlap
ChIP K562 ENCFF185FKB 361 bp overlap
ChIP K562 ENCFF501CDP 375 bp overlap
ZNF316 1 dataset
ChIP K562 ENCFF838QCD 220 bp overlap
ZNF750 1 dataset
ChIP keratinocyte_diff GSE57702.ZNF750.keratinocyte_diff 253 bp overlap