The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for STAG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:123,764,958–123,765,499 | 195.5 kb | Distal (>10kb) Multiome | 449 | |
| chrX:123,777,153–123,778,268 | 182.9 kb | Distal (>10kb) Multiome | 304 | |
| chrX:123,819,503–123,820,137 | 140.9 kb | Distal (>10kb) Multiome | 137 | |
| chrX:123,859,576–123,860,648 | 100.7 kb | Distal (>10kb) Multiome | 739 | |
| chrX:123,864,842–123,865,356 | 95.6 kb | Distal (>10kb) Multiome | 63 | |
| chrX:123,959,874–123,960,635 | 308 bp | At TSS Multiome | 606 | |
| chrX:123,960,800–123,962,121 | 989 bp | At TSS Multiome | 588 | |
| chrX:123,962,799–123,963,352 | 2.5 kb | Proximal (<10kb) Multiome | 545 |
Genomic view of the STAG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.