This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for FOXL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:138,935,795–138,937,399 | 9.7 kb | Proximal (<10kb) | 594 | |
| chr3:138,937,821–138,938,914 | 8.2 kb | Proximal (<10kb) | 119 | |
| chr3:138,939,448–138,940,032 | 7.1 kb | Proximal (<10kb) | 138 | |
| chr3:138,941,163–138,941,584 | 5.6 kb | Proximal (<10kb) | 153 | |
| chr3:138,943,179–138,943,567 | 3.6 kb | Proximal (<10kb) | 131 | |
| chr3:138,944,879–138,947,892 | at TSS | At TSS | 500 | |
| chr3:138,949,729–138,950,605 | 2.6 kb | Proximal (<10kb) | 149 |
Genomic view of the FOXL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.