This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for UBTF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBTF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBTF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:43,937,932–43,938,382 | 283.0 kb | Distal (>10kb) Multiome | 757 | |
| chr17:43,952,298–43,953,752 | 268.2 kb | Distal (>10kb) Multiome | 295 | |
| chr17:43,983,489–43,984,364 | 237.2 kb | Distal (>10kb) Multiome | 743 | |
| chr17:44,004,236–44,007,875 | 216.5 kb | Distal (>10kb) Multiome | 807 | |
| chr17:44,014,255–44,015,168 | 206.3 kb | Distal (>10kb) Multiome | 1020 | |
| chr17:44,066,017–44,066,857 | 154.6 kb | Distal (>10kb) Multiome | 722 | |
| chr17:44,070,107–44,071,340 | 150.5 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:44,095,480–44,096,263 | 125.3 kb | Distal (>10kb) Multiome | 713 | |
| chr17:44,110,949–44,111,605 | 110.0 kb | Distal (>10kb) Multiome | 856 | |
| chr17:44,122,999–44,124,340 | 97.4 kb | Distal (>10kb) Multiome | 883 | |
| chr17:44,141,505–44,142,741 | 79.4 kb | Distal (>10kb) Multiome | 857 | |
| chr17:44,168,259–44,168,849 | 52.6 kb | Distal (>10kb) Multiome | 475 | |
| chr17:44,186,111–44,187,514 | 34.4 kb | Distal (>10kb) Multiome | 917 | |
| chr17:44,198,550–44,201,037 | 21.1 kb | Distal (>10kb) Multiome | 868 | |
| chr17:44,210,257–44,210,930 | 10.7 kb | Distal (>10kb) Multiome | 568 | |
| chr17:44,218,107–44,221,629 | 2.6 kb | Proximal (<10kb) Multiome | 936 | |
| chr17:44,221,765–44,222,816 | 1.1 kb | Proximal (<10kb) Multiome | 597 | |
| chr17:44,307,755–44,309,164 | 87.3 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr17:44,314,945–44,315,776 | 94.0 kb | Distal (>10kb) Multiome HiCAR | 273 | |
| chr17:44,316,273–44,316,728 | 95.2 kb | Distal (>10kb) Multiome HiCAR | 183 | |
| chr17:44,324,218–44,325,841 | 103.7 kb | Distal (>10kb) Multiome HiCAR | 852 | |
| chr17:44,326,610–44,327,149 | 105.8 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr17:44,344,826–44,346,001 | 124.0 kb | Distal (>10kb) Multiome HiCAR | 837 | |
| chr17:44,353,667–44,355,182 | 133.5 kb | Distal (>10kb) Multiome HiCAR | 393 | |
| chr17:44,363,447–44,364,077 | 142.6 kb | Distal (>10kb) Multiome | 502 | |
| chr17:44,374,688–44,375,216 | 153.6 kb | Distal (>10kb) Multiome | 299 | |
| chr17:44,384,542–44,386,175 | 164.2 kb | Distal (>10kb) Multiome | 553 | |
| chr17:44,502,912–44,504,091 | 282.3 kb | Distal (>10kb) Multiome | 999 |
Genomic view of the UBTF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.