chr2:64,114,439–64,115,073

chr2 : 64,114,439 – 64,115,073

634 bp 98 TFs 5 linked genes

This 634 bp open chromatin element is linked to 5 target genes and is bound by 98 transcription factors.

Linked Genes

5 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PELI1		29.7 kb	Distal	Multiome
VPS54		95.2 kb	Distal	Multiome
ENSG00000225889		113.7 kb	Distal	Multiome
ENSG00000288932		159.0 kb	Distal	Multiome
UGP2		273.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

98 transcription factors

ARID1A 2 datasets

ChIP 12Z GSE129781.ARID1A.12Z 99 bp overlap

ChIP endometrial-epithelial-cells GSE106660.ARID1A.endometrial-epithelial-cells 118 bp overlap

ARID3A 2 datasets

ChIP GM12878 ENCSR778UBR.ARID3A.GM12878 125 bp overlap

ChIP GM12878 ENCSR725LYT.ARID3A.GM12878 95 bp overlap

Motif DE_72h DE_72h-ATF4_MA0833.3 10 bp overlap

ChIP GM12878 ENCFF037PYH 59 bp overlap

BCLAF1 1 dataset

ChIP GM12878 ENCFF306JRM 218 bp overlap

BRD4 13 datasets

ChIP CD4_JG1 GSE33281.BRD4.CD4_JG1 262 bp overlap

ChIP CLL_patient1 GSE109411.BRD4.CLL_patient1 286 bp overlap

ChIP CLL_patient3_4h_CpG GSE109411.BRD4.CLL_patient3_4h_CpG 502 bp overlap

ChIP CLL_patient4_4h_CpG GSE109411.BRD4.CLL_patient4_4h_CpG 269 bp overlap

ChIP GM15850_PA1_JQ1 GSE99402.BRD4.GM15850_PA1_JQ1 416 bp overlap

ChIP HCC1937 GSE124748.BRD4.HCC1937 418 bp overlap

ChIP HT29 GSE73319.BRD4.HT29 229 bp overlap

ChIP HT29 GSE73319.BRD4.HT29 229 bp overlap

ChIP MDA-MB-231_MGSK2801 GSE116879.BRD4.MDA-MB-231_MGSK2801 53 bp overlap

ChIP MDA-MB-231_MGSK2801_rDNA GSE116879.BRD4.MDA-MB-231_MGSK2801_rDNA 53 bp overlap

ChIP Mutu-1_vehicle GSE84213.BRD4.Mutu-1_vehicle 237 bp overlap

ChIP SUM159PT_30nMbortezomib_8h GSE87418.BRD4.SUM159PT_30nMbortezomib_8h 147 bp overlap

ChIP T-cell_DMSO GSE138084.BRD4.T-cell_DMSO 80 bp overlap

ChIP GM12878 ENCFF056JUS 53 bp overlap

ChIP KB_IL GSE52469.CDK6.KB_IL 100 bp overlap

CDX2 2 datasets

ChIP LS180 GSE31939.CDX2.LS180 217 bp overlap

ChIP LS180_125 GSE31939.CDX2.LS180_125 96 bp overlap

CEBPB 1 dataset

ChIP HFOB_DIFF GSE82295.CEBPB.HFOB_DIFF 79 bp overlap

CREBBP 4 datasets

ChIP PC-3 GSE147455.CREBBP.PC-3 166 bp overlap

ChIP PC-3 GSE147455.CREBBP.PC-3 269 bp overlap

ChIP PC-3_GDC-resist GSE147455.CREBBP.PC-3_GDC-resist 170 bp overlap

ChIP keratinocyte_KLF3i GSE140991.CREBBP.keratinocyte_KLF3i 221 bp overlap

CTCF 4 datasets

ChIP B cell ENCFF506FKC 267 bp overlap

ChIP B cell ENCFF506FKC 481 bp overlap

ChIP colon_transverse ENCSR833FWC.CTCF.colon_transverse 115 bp overlap

ChIP transverse colon ENCFF077CMZ 186 bp overlap

DPF2 2 datasets

ChIP GM12878 ENCFF681AJV 186 bp overlap

ChIP GM12878 ENCSR509FWH.DPF2.GM12878 294 bp overlap

E2F6 2 datasets

Motif DE_48h DE_48h-E2F6_MA0471.3 8 bp overlap

Motif DE_72h DE_72h-E2F6_MA0471.3 8 bp overlap

ChIP GM12878 ENCFF266FYW 84 bp overlap

ChIP GM12878 ENCFF266FYW 297 bp overlap

ELF3 3 datasets

ChIP PDAC GSE64557.ELF3.PDAC 240 bp overlap

ChIP PDAC_KOKLF5 GSE64557.ELF3.PDAC_KOKLF5 260 bp overlap

ChIP PDAC_SHCTR GSE64557.ELF3.PDAC_SHCTR 258 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 172 bp overlap

ChIP HUVEC-C_VEGF_12H GSE41166.ETS1.HUVEC-C_VEGF_12H 162 bp overlap

ETV5::DRGX 1 dataset

Motif DE_72h DE_72h-ETV5DRGX_MA1944.2 12 bp overlap

ChIP GM12878 ENCFF105ZMI 243 bp overlap

ChIP SKH1_10d GSE87283.EVI1.SKH1_10d 155 bp overlap

ChIP GM23248 ENCFF506FWX 70 bp overlap

FIGLA 2 datasets

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap

ChIP CD4 GSE116695.FOS.CD4 123 bp overlap

ChIP CFPAC-1 GSE119930.FOS.CFPAC-1 111 bp overlap

FOSL2 1 dataset

ChIP MCF-7 ENCFF188KBZ 138 bp overlap

FOXA1 6 datasets

ChIP CFPAC-1 GSE119930.FOXA1.CFPAC-1 191 bp overlap

ChIP CFPAC-1_FOXA2-KO GSE119930.FOXA1.CFPAC-1_FOXA2-KO 123 bp overlap

ChIP PDAC GSE64557.FOXA1.PDAC 86 bp overlap

ChIP PDAC_KOKLF5 GSE64557.FOXA1.PDAC_KOKLF5 184 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 297 bp overlap

ChIP primary-prostate-cancer_P2_DSG GSE114737.FOXA1.primary-prostate-cancer_P2_DSG 185 bp overlap

FOXA2 9 datasets

ChIP CFPAC-1 GSE119930.FOXA2.CFPAC-1 167 bp overlap

ChIP CFPAC-1_EV GSE119930.FOXA2.CFPAC-1_EV 86 bp overlap

ChIP CFPAC-1_HOXB8-OE GSE119930.FOXA2.CFPAC-1_HOXB8-OE 205 bp overlap

ChIP DE DE-FOXA2-1 634 bp overlap

ChIP DE DE-FOXA2-2 634 bp overlap

ChIP PANC-1 GSE119930.FOXA2.PANC-1 126 bp overlap

ChIP PANC-1_EV GSE119930.FOXA2.PANC-1_EV 143 bp overlap

ChIP PANC-1_HNF1B-OE GSE119930.FOXA2.PANC-1_HNF1B-OE 288 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 297 bp overlap

FOXL2 1 dataset

ChIP KGN_1513 GSE138496.FOXL2.KGN_1513 91 bp overlap

GABPA 1 dataset

ChIP VCaP GSE49091.GABPA.VCaP 110 bp overlap

GATA1 1 dataset

Motif DE_72h DE_72h-GATA1_MA0035.5 7 bp overlap

GATA4 8 datasets

ChIP A-549 GSE85002.GATA4.A-549 187 bp overlap

ChIP A-549 GSE85002.GATA4.A-549 229 bp overlap

ChIP BJ1-hTERT GSE92491.GATA4.BJ1-hTERT 163 bp overlap

ChIP DE DE-GATA4-1 634 bp overlap

ChIP DE DE-GATA4-2 634 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 220 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 634 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 477 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 574 bp overlap

ChIP DE DE-GATA6-2 634 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 326 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 598 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 352 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 259 bp overlap

ChIP OACP4-C GSE132680.GATA6.OACP4-C 194 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 578 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 407 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 427 bp overlap

HDAC2 1 dataset

ChIP PC-3 GSE147455.HDAC2.PC-3 353 bp overlap

HNF1B 1 dataset

ChIP PDAC GSE64557.HNF1B.PDAC 174 bp overlap

HOXB8 1 dataset

ChIP CFPAC-1_HOXB8-OE GSE119930.HOXB8.CFPAC-1_HOXB8-OE 59 bp overlap

IKZF1 2 datasets

ChIP GM12878 ENCFF824TGK 148 bp overlap

ChIP GM12878 ENCFF824TGK 349 bp overlap

IKZF2 3 datasets

ChIP GM12878 ENCFF238LYK 366 bp overlap

ChIP GM12878 ENCSR822AHX.IKZF2.GM12878 123 bp overlap

ChIP GM12878 ENCSR680UQE.IKZF2.GM12878 82 bp overlap

IRF4 5 datasets

ChIP B-cell GSE142493.IRF4.B-cell 338 bp overlap

ChIP BC-3 GSE132777.IRF4.BC-3 72 bp overlap

ChIP BC-3 GSE132777.IRF4.BC-3 193 bp overlap

ChIP OCI-Ly10 GSE142493.IRF4.OCI-Ly10 203 bp overlap

ChIP T-cell GSE136853.IRF4.T-cell 381 bp overlap

ChIP Karpas-299 GSE151413.JUN.Karpas-299 634 bp overlap

JUNB 3 datasets

ChIP CD4 GSE116695.JUNB.CD4 113 bp overlap

ChIP CFPAC-1 GSE119930.JUNB.CFPAC-1 177 bp overlap

ChIP GM12878 ENCSR897MMC.JUNB.GM12878 133 bp overlap

KDM1A 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.KDM1A.pancreatic-progenitor_PP1 351 bp overlap

KLF17 2 datasets

Motif DE_48h DE_48h-KLF17_MA1514.2 14 bp overlap

Motif DE_72h DE_72h-KLF17_MA1514.2 14 bp overlap

KMT2A 1 dataset

ChIP blood_cord GSE83671.KMT2A.blood_cord 62 bp overlap

ChIP P493-6_CMYC_1H GSE36354.MAX.P493-6_CMYC_1H 166 bp overlap

ChIP MDA-MB-231_LQ GSE95121.MED1.MDA-MB-231_LQ 207 bp overlap

MLLT1 2 datasets

ChIP GM12878 ENCFF995GXC 141 bp overlap

ChIP GM12878 ENCSR552XSN.MLLT1.GM12878 96 bp overlap

ChIP GM12878 ENCFF615CWQ 85 bp overlap

ChIP GM12878 ENCFF666NJR 431 bp overlap

MYOD1 2 datasets

Motif DE_48h DE_48h-MYOD1_MA0499.3 9 bp overlap

Motif DE_72h DE_72h-MYOD1_MA0499.3 9 bp overlap

NFATC2 3 datasets

ChIP CD4 GSE116695.NFATC2.CD4 158 bp overlap

ChIP CD4_CD28-ab GSE116695.NFATC2.CD4_CD28-ab 150 bp overlap

ChIP CD4_fly-DNA GSE116695.NFATC2.CD4_fly-DNA 102 bp overlap

NFATC3 1 dataset

ChIP GM12878 ENCFF340KVJ 85 bp overlap

ChIP GM12878 ENCSR000BRN.NFIC.GM12878 95 bp overlap

NIPBL 1 dataset

ChIP GP5D GSE51234.NIPBL.GP5D 83 bp overlap

NKX2-1 1 dataset

ChIP NCI-H3122 GSE39998.NKX2-1.NCI-H3122 120 bp overlap

POLR2A 6 datasets

ChIP GM12878 ENCFF263VRI 244 bp overlap

ChIP GM12878 ENCFF263VRI 443 bp overlap

ChIP GM12878 ENCFF412KAE 371 bp overlap

ChIP GM12878 ENCFF412KAE 606 bp overlap

ChIP body of pancreas ENCFF501FEC 285 bp overlap

ChIP body of pancreas ENCFF501FEC 628 bp overlap

POU5F1 1 dataset

ChIP BJ_INDUCED GSE36570.POU5F1.BJ_INDUCED 137 bp overlap

PRDM10 1 dataset

ChIP HEK293 ENCFF145WQQ 329 bp overlap

PRDM6 1 dataset

ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 146 bp overlap

PROX1 2 datasets

ChIP SW480 GSE60390.PROX1.SW480 168 bp overlap

ChIP SW480 GSE60390.PROX1.SW480 85 bp overlap

Ptf1A 2 datasets

Motif DE_48h DE_48h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_72h DE_72h-Ptf1A_MA1620.2 8 bp overlap

RAD21 3 datasets

ChIP GP5D GSE51234.RAD21.GP5D 244 bp overlap

ChIP MDM_-dNS1 GSE103477.RAD21.MDM_-dNS1 278 bp overlap

ChIP peripheral-blood-neutrophil_US-1 GSE126755.RAD21.peripheral-blood-neutrophil_US-1 140 bp overlap

RBPJ 5 datasets

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

Motif DE_72h DE_72h-RBPJ_MA1116.2 6 bp overlap

Motif DE_72h DE_72h-RBPJ_MA1116.2 6 bp overlap

ChIP LCL GSE75503.RBPJ.LCL 158 bp overlap

ChIP NHEK GSE29498.RBPJ.NHEK 199 bp overlap

RELA 4 datasets

ChIP Detroit-562_TNFa GSE91018.RELA.Detroit-562_TNFa 76 bp overlap

ChIP aortic-endothelial-cell_IL1B_D16 GSE139377.RELA.aortic-endothelial-cell_IL1B_D16 55 bp overlap

ChIP aortic-endothelial-cell_IL1B_D39 GSE139377.RELA.aortic-endothelial-cell_IL1B_D39 173 bp overlap

ChIP aortic-endothelial-cell_IL1B_D9 GSE139377.RELA.aortic-endothelial-cell_IL1B_D9 65 bp overlap

RELB 3 datasets

ChIP GM12878 ENCFF217ADF 105 bp overlap

ChIP GM12878 ENCFF217ADF 306 bp overlap

ChIP GM12878 ENCSR387QUV.RELB.GM12878 383 bp overlap

SIN3A 1 dataset

ChIP HUVEC-C GSE103245.SIN3A.HUVEC-C 136 bp overlap

ChIP GM12878 ENCFF171OVM 94 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 634 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 414 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 330 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 292 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 357 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 306 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 471 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 459 bp overlap

SMARCA2 1 dataset

ChIP NPC_R1159Q_AM GSE122631.SMARCA2.NPC_R1159Q_AM 216 bp overlap

SMARCA4 3 datasets

ChIP A-549_AG15686 GSE132290.SMARCA4.A-549_AG15686 53 bp overlap

ChIP NPC_K755R-siCT GSE122631.SMARCA4.NPC_K755R-siCT 118 bp overlap

ChIP endometrial-epithelial-cells_KO GSE106660.SMARCA4.endometrial-epithelial-cells_KO 494 bp overlap

SMARCA5 2 datasets

ChIP GM12878 ENCFF327LDR 437 bp overlap

ChIP GM12878 ENCSR706YUH.SMARCA5.GM12878 288 bp overlap

SMARCB1 1 dataset

ChIP MCF-7_estrogen GSE123284.SMARCB1.MCF-7_estrogen 177 bp overlap

SNAI2 3 datasets

Motif DE_48h DE_48h-SNAI2_MA0745.3 8 bp overlap

Motif DE_72h DE_72h-SNAI2_MA0745.3 8 bp overlap

ChIP PC-9_2DF GSE131687.SNAI2.PC-9_2DF 357 bp overlap

ChIP NHEK GSE29498.SND1.NHEK 188 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 458 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 222 bp overlap

SPI1 6 datasets

ChIP DC_96h_donorM GSE128834.SPI1.DC_96h_donorM 200 bp overlap

ChIP GM12891 ENCFF563IUT 182 bp overlap

ChIP Kasumi-1_SIRUNX1ETO GSE60130.SPI1.Kasumi-1_SIRUNX1ETO 148 bp overlap

ChIP OCI-Ly7 GSE69558.SPI1.OCI-Ly7 130 bp overlap

ChIP primary-neutrophil_donorE GSE128834.SPI1.primary-neutrophil_donorE 107 bp overlap

ChIP primary-neutrophil_donorF GSE128834.SPI1.primary-neutrophil_donorF 120 bp overlap

SREBP2 1 dataset

ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 63 bp overlap

STAT1 1 dataset

ChIP CD14_INFG_LPS GSE43036.STAT1.CD14_INFG_LPS 174 bp overlap

STAT3 1 dataset

ChIP monocyte_IFNg-LPS GSE120943.STAT3.monocyte_IFNg-LPS 278 bp overlap

STAT5A 1 dataset

ChIP GM12878 ENCFF267JUM 108 bp overlap

SUPT5H 1 dataset

ChIP DLD-1_NELFCD-AID_treated GSE144786.SUPT5H.DLD-1_NELFCD-AID_treated 259 bp overlap

Motif DE_72h DE_72h-Six3_MA0631.2 11 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 365 bp overlap

TARDBP 1 dataset

ChIP GM12878 ENCSR412QBS.TARDBP.GM12878 214 bp overlap

TBX21 1 dataset

ChIP GM12878 ENCSR739IHN.TBX21.GM12878 388 bp overlap

TEAD1 1 dataset

ChIP HUCCT1 GSE68296.TEAD1.HUCCT1 176 bp overlap

TERF1 1 dataset

ChIP LCL GSE55053.TERF1.LCL 144 bp overlap

TERF2 1 dataset

ChIP LCL GSE55053.TERF2.LCL 247 bp overlap

TFAP4 1 dataset

ChIP DLD-1 GSE46935.TFAP4.DLD-1 170 bp overlap

Tbx6 2 datasets

Motif DE_48h DE_48h-Tbx6_MA1567.3 9 bp overlap

Motif DE_72h DE_72h-Tbx6_MA1567.3 9 bp overlap

ChIP MDA-MB-231 GSE66081.YAP1.MDA-MB-231 231 bp overlap

ChIP ALL GSE145549.YY1.ALL 75 bp overlap

YY1AP1 1 dataset

ChIP PC-9_1DF GSE131687.YY1AP1.PC-9_1DF 147 bp overlap

ZEB1 2 datasets

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap

ZNF211 1 dataset

Motif DE_72h DE_72h-ZNF211_MA1974.2 10 bp overlap

ZNF217 1 dataset

ChIP GM12878 ENCSR764CZW.ZNF217.GM12878 80 bp overlap

ZNF85 1 dataset

Motif DE_72h DE_72h-ZNF85_MA1720.2 12 bp overlap