This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IKZF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IKZF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IKZF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:213,150,035–213,150,894 | at TSS | At TSS | 295 | |
| chr2:213,151,332–213,152,642 | 230 bp | At TSS Multiome | 709 | |
| chr2:213,153,561–213,154,389 | 3.2 kb | Proximal (<10kb) | 246 | |
| chr2:213,155,809–213,156,562 | 4.6 kb | Proximal (<10kb) Multiome | 149 | |
| chr2:213,189,020–213,190,112 | 38.0 kb | Distal (>10kb) Multiome | 218 | |
| chr2:213,283,867–213,285,119 | 132.8 kb | Distal (>10kb) Multiome | 863 | |
| chr2:215,089,705–215,091,041 | 1938.6 kb | Distal (>10kb) Multiome HiCAR | 134 |
Genomic view of the IKZF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.