This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Multiple transcripts of this gene are alternatively spliced products. [provided by RefSeq, Aug 2022]
Transcription factors with Perturb-seq knockdown data for TERF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TERF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TERF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:72,709,330–72,710,180 | 299.1 kb | Distal (>10kb) Multiome | 109 | |
| chr8:72,972,189–72,972,746 | 36.3 kb | Distal (>10kb) Multiome | 126 | |
| chr8:73,001,884–73,002,270 | 6.6 kb | Proximal (<10kb) | 150 | |
| chr8:73,002,574–73,003,142 | 5.7 kb | Proximal (<10kb) | 12 | |
| chr8:73,008,165–73,009,389 | 70 bp | At TSS Multiome | 699 | |
| chr8:73,009,499–73,010,105 | 644 bp | At TSS | 136 | |
| chr8:73,092,506–73,093,728 | 84.3 kb | Distal (>10kb) Multiome | 249 | |
| chr8:73,174,013–73,174,795 | 165.6 kb | Distal (>10kb) Multiome | 447 | |
| chr8:73,285,133–73,286,577 | 277.0 kb | Distal (>10kb) Multiome | 282 | |
| chr8:73,293,182–73,296,152 | 285.3 kb | Distal (>10kb) Multiome | 1030 |
Genomic view of the TERF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.