Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF85. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF85 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF85, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:20,565,337–20,566,048 | 357.5 kb | Distal (>10kb) Multiome HiCAR | 386 | |
| chr19:20,660,950–20,661,849 | 261.6 kb | Distal (>10kb) Multiome | 315 | |
| chr19:20,665,001–20,665,677 | 257.9 kb | Distal (>10kb) Multiome | 99 | |
| chr19:20,776,028–20,776,925 | 147.0 kb | Distal (>10kb) Multiome | 329 | |
| chr19:20,922,848–20,923,737 | 39 bp | At TSS Multiome | 286 | |
| chr19:20,999,685–21,000,422 | 76.7 kb | Distal (>10kb) Multiome | 234 | |
| chr19:21,020,242–21,021,293 | 97.4 kb | Distal (>10kb) Multiome | 466 | |
| chr19:21,081,742–21,082,659 | 158.9 kb | Distal (>10kb) Multiome | 412 | |
| chr19:21,141,765–21,142,544 | 218.8 kb | Distal (>10kb) Multiome | 378 |
Genomic view of the ZNF85 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.