SKIL

SKI like proto-oncogene | SNO, SnoA, SnoN

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Member of: DE-10 DE-10.8 Developmental clusters: GC5

Biological processes 40 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)PML body (GO:0016605)PML body (GO:0016605)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)SMAD binding (GO:0046332)SMAD binding (GO:0046332)SMAD binding (GO:0046332)acrosomal vesicle (GO:0001669)chromatin binding (GO:0003682)cytoplasm (GO:0005737)cytoplasm (GO:0005737)identical protein binding (GO:0042802)muscle structure development (GO:0061061)negative regulation of BMP signaling pathway (GO:0030514)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of axonogenesis (GO:0050772)positive regulation of axonogenesis (GO:0050772)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)regulation of neurogenesis (GO:0050767)response to antibiotic (GO:0046677)response to cytokine (GO:0034097)response to growth factor (GO:0070848)skeletal muscle tissue development (GO:0007519)spermatogenesis (GO:0007283)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating SKIL 0 TFs

Transcription factors with Perturb-seq knockdown data for SKIL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKIL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SKIL

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKIL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:170,180,833–170,182,100	176.0 kb	Distal (>10kb) Multiome	813
chr3:170,221,926–170,223,285	135.3 kb	Distal (>10kb) Multiome	847
chr3:170,356,326–170,358,653	430 bp	At TSS Multiome	971
chr3:170,418,375–170,421,188	61.1 kb	Distal (>10kb) Multiome	413
chr3:170,425,589–170,426,593	68.5 kb	Distal (>10kb) Multiome	432
chr3:170,476,158–170,477,136	118.9 kb	Distal (>10kb) Multiome	116
chr3:170,584,438–170,585,040	227.1 kb	Distal (>10kb) Multiome	442
chr3:170,585,131–170,586,475	228.4 kb	Distal (>10kb) Multiome	234

Genome Browser

Genomic view of the SKIL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.