The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UGP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UGP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UGP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:63,572,050–63,572,620 | 268.7 kb | Distal (>10kb) Multiome | 43 | |
| chr2:63,587,861–63,589,431 | 252.2 kb | Distal (>10kb) Multiome | 1009 | |
| chr2:63,600,759–63,601,822 | 239.6 kb | Distal (>10kb) Multiome | 194 | |
| chr2:63,746,437–63,747,016 | 94.2 kb | Distal (>10kb) Multiome | 145 | |
| chr2:63,840,151–63,842,662 | 763 bp | At TSS Multiome | 1134 | |
| chr2:63,847,418–63,847,932 | 6.4 kb | Proximal (<10kb) | 44 | |
| chr2:63,849,590–63,849,845 | 8.6 kb | Proximal (<10kb) | 81 | |
| chr2:63,950,012–63,950,802 | 109.6 kb | Distal (>10kb) Multiome | 117 | |
| chr2:64,018,646–64,019,987 | 178.3 kb | Distal (>10kb) Multiome | 831 | |
| chr2:64,073,896–64,076,052 | 233.9 kb | Distal (>10kb) Multiome | 154 | |
| chr2:64,114,439–64,115,073 | 273.7 kb | Distal (>10kb) Multiome | 98 |
Genomic view of the UGP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.