NFATC2

nuclear factor of activated T cells 2 | NF-ATP, NFAT1, NFATp

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Biological processes 52 terms

14-3-3 protein binding (GO:0071889)B cell receptor signaling pathway (GO:0050853)DNA binding (GO:0003677)DNA binding (GO:0003677)DNA damage response (GO:0006974)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)calcineurin-NFAT signaling cascade (GO:0033173)cartilage development (GO:0051216)cartilage development (GO:0051216)cell migration (GO:0016477)chromatin (GO:0000785)chromatin (GO:0000785)chromatin binding (GO:0003682)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)molecular adaptor activity (GO:0060090)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of vascular associated smooth muscle cell differentiation (GO:1905064)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)phosphatase binding (GO:0019902)positive regulation of B cell proliferation (GO:0030890)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of gene expression (GO:0010628)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)response to xenobiotic stimulus (GO:0009410)ribonucleoprotein complex (GO:1990904)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)transcription regulator complex (GO:0005667)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating NFATC2 0 TFs

Transcription factors with Perturb-seq knockdown data for NFATC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFATC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NFATC2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFATC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:50,992,251–50,993,606	569.5 kb	Distal (>10kb) Multiome HiCAR	409
chr20:51,305,036–51,307,268	256.9 kb	Distal (>10kb) Multiome	587
chr20:51,308,313–51,308,876	254.1 kb	Distal (>10kb) Multiome	27
chr20:51,373,737–51,374,717	188.4 kb	Distal (>10kb) Multiome	259
chr20:51,449,050–51,449,553	113.3 kb	Distal (>10kb) Multiome	56
chr20:51,541,209–51,541,595	1.1 kb	Proximal (<10kb)	556
chr20:51,542,047–51,542,945	19.9 kb	Distal (>10kb) Multiome	490
chr20:51,562,201–51,563,176	10 bp	At TSS Multiome	525
chr20:51,564,068–51,564,265	1.4 kb	Proximal (<10kb)	180
chr20:51,766,950–51,768,471	204.7 kb	Distal (>10kb) Multiome	740
chr20:51,797,358–51,798,525	235.3 kb	Distal (>10kb) Multiome	273
chr20:51,799,751–51,800,876	237.8 kb	Distal (>10kb) Multiome	661
chr20:51,801,027–51,803,202	240.0 kb	Distal (>10kb) Multiome	615

Genome Browser

Genomic view of the NFATC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.