TFs regulating ENSG00000225889 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000225889. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000225889 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000225889

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000225889, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:63,950,012–63,950,802	277.8 kb	Distal (>10kb) Multiome	117
chr2:64,018,646–64,019,987	209.1 kb	Distal (>10kb) Multiome	831
chr2:64,073,896–64,076,052	153.5 kb	Distal (>10kb) Multiome	154
chr2:64,114,439–64,115,073	113.7 kb	Distal (>10kb) Multiome	98
chr2:64,143,692–64,145,137	83.9 kb	Distal (>10kb) Multiome	843
chr2:64,227,941–64,228,667	34 bp	At TSS Multiome	493
chr2:64,251,480–64,252,200	23.3 kb	Distal (>10kb) Multiome	104
chr2:64,252,396–64,252,854	24.4 kb	Distal (>10kb) Multiome	93
chr2:64,276,376–64,277,307	48.4 kb	Distal (>10kb) Multiome	252
chr2:64,330,958–64,331,642	102.9 kb	Distal (>10kb) Multiome	275
chr2:64,404,071–64,404,983	176.0 kb	Distal (>10kb) Multiome	340
chr2:64,453,131–64,455,109	225.9 kb	Distal (>10kb) Multiome	767
chr2:64,459,486–64,459,967	231.3 kb	Distal (>10kb) Multiome	89
chr2:64,523,863–64,525,127	295.9 kb	Distal (>10kb) Multiome	964

Genome Browser

Genomic view of the ENSG00000225889 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.