This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for SND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:127,391,433–127,393,629 | 259.5 kb | Distal (>10kb) Multiome | 929 | |
| chr7:127,584,951–127,586,129 | 66.6 kb | Distal (>10kb) Multiome | 808 | |
| chr7:127,587,636–127,589,370 | 63.8 kb | Distal (>10kb) Multiome | 807 | |
| chr7:127,619,493–127,621,269 | 31.9 kb | Distal (>10kb) Multiome | 302 | |
| chr7:127,628,938–127,629,789 | 22.7 kb | Distal (>10kb) Multiome | 216 | |
| chr7:127,650,994–127,652,678 | 232 bp | At TSS Multiome | 1039 | |
| chr7:127,665,882–127,666,444 | 13.9 kb | Distal (>10kb) Multiome | 161 | |
| chr7:128,030,162–128,033,072 | 380.3 kb | Distal (>10kb) Multiome HiCAR | 422 | |
| chr7:128,166,496–128,169,100 | 516.5 kb | Distal (>10kb) Multiome HiCAR | 559 | |
| chr7:128,200,949–128,201,858 | 549.2 kb | Distal (>10kb) Multiome HiCAR | 168 |
Genomic view of the SND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.