The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for PROX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PROX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PROX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:213,693,743–213,694,416 | 293.9 kb | Distal (>10kb) Multiome | 89 | |
| chr1:213,976,772–213,977,929 | 10.7 kb | Distal (>10kb) Multiome | 346 | |
| chr1:213,978,867–213,979,028 | 8.9 kb | Proximal (<10kb) | 10 | |
| chr1:213,979,557–213,980,562 | 7.9 kb | Proximal (<10kb) Multiome | 196 | |
| chr1:213,982,546–213,986,860 | 3.4 kb | Proximal (<10kb) Multiome | 731 | |
| chr1:213,987,385–213,990,006 | 42 bp | At TSS Multiome | 745 | |
| chr1:214,122,937–214,123,675 | 135.4 kb | Distal (>10kb) Multiome HiCAR | 368 | |
| chr1:214,154,263–214,155,345 | 166.8 kb | Distal (>10kb) Multiome | 230 | |
| chr1:214,280,447–214,282,049 | 293.3 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the PROX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.