Enables ubiquitin-ubiquitin ligase activity. Involved in several processes, including negative regulation of TORC1 signaling; negative regulation of necroptotic process; and protein polyubiquitination. Is active in site of double-strand break. Implicated in colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PELI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PELI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PELI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:63,950,012–63,950,802 | 193.8 kb | Distal (>10kb) Multiome | 117 | |
| chr2:64,018,646–64,019,987 | 125.1 kb | Distal (>10kb) Multiome | 831 | |
| chr2:64,073,896–64,076,052 | 69.5 kb | Distal (>10kb) Multiome | 154 | |
| chr2:64,114,439–64,115,073 | 29.7 kb | Distal (>10kb) Multiome | 98 | |
| chr2:64,143,692–64,145,137 | 113 bp | At TSS Multiome | 843 | |
| chr2:64,145,247–64,146,245 | 851 bp | At TSS | 90 | |
| chr2:64,227,941–64,228,667 | 83.9 kb | Distal (>10kb) Multiome | 493 | |
| chr2:64,251,480–64,252,200 | 107.3 kb | Distal (>10kb) Multiome HiCAR | 104 | |
| chr2:64,252,396–64,252,854 | 108.4 kb | Distal (>10kb) Multiome HiCAR | 93 | |
| chr2:64,276,376–64,277,307 | 132.4 kb | Distal (>10kb) Multiome | 252 | |
| chr2:64,330,958–64,331,642 | 186.9 kb | Distal (>10kb) Multiome | 275 | |
| chr2:64,404,071–64,404,983 | 260.0 kb | Distal (>10kb) Multiome | 340 |
Genomic view of the PELI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.