Involved in cell differentiation; cell population proliferation; and regulation of cell cycle. Located in Ino80 complex; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for YY1AP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YY1AP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YY1AP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:155,562,014–155,563,482 | 126.0 kb | Distal (>10kb) Multiome | 909 | |
| chr1:155,609,731–155,610,295 | 78.9 kb | Distal (>10kb) Multiome | 503 | |
| chr1:155,688,087–155,689,328 | 151 bp | At TSS Multiome | 838 | |
| chr1:155,745,339–155,745,870 | 56.7 kb | Distal (>10kb) Multiome | 505 | |
| chr1:155,806,537–155,807,073 | 117.8 kb | Distal (>10kb) Multiome | 15 | |
| chr1:155,856,932–155,857,529 | 168.3 kb | Distal (>10kb) Multiome | 639 | |
| chr1:155,859,095–155,860,745 | 170.4 kb | Distal (>10kb) Multiome | 632 | |
| chr1:155,910,686–155,911,579 | 222.4 kb | Distal (>10kb) Multiome | 691 | |
| chr1:155,934,107–155,934,787 | 245.5 kb | Distal (>10kb) Multiome | 872 | |
| chr1:155,976,727–155,977,187 | 287.9 kb | Distal (>10kb) Multiome | 316 | |
| chr1:155,977,296–155,979,264 | 289.7 kb | Distal (>10kb) Multiome | 698 |
Genomic view of the YY1AP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.