Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II transcription regulator complex. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATF7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATF7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATF7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:53,344,427–53,345,660 | 281.4 kb | Distal (>10kb) Multiome | 645 | |
| chr12:53,370,910–53,371,893 | 255.0 kb | Distal (>10kb) Multiome | 861 | |
| chr12:53,378,839–53,381,297 | 245.8 kb | Distal (>10kb) Multiome | 895 | |
| chr12:53,381,689–53,382,262 | 244.3 kb | Distal (>10kb) Multiome | 264 | |
| chr12:53,421,253–53,422,044 | 204.7 kb | Distal (>10kb) Multiome | 431 | |
| chr12:53,440,979–53,441,838 | 184.8 kb | Distal (>10kb) Multiome | 779 | |
| chr12:53,451,563–53,453,067 | 174.4 kb | Distal (>10kb) Multiome | 999 | |
| chr12:53,492,147–53,494,149 | 133.3 kb | Distal (>10kb) Multiome | 702 | |
| chr12:53,498,714–53,500,111 | 126.9 kb | Distal (>10kb) Multiome | 454 | |
| chr12:53,500,242–53,501,839 | 125.4 kb | Distal (>10kb) Multiome | 1010 | |
| chr12:53,625,664–53,626,787 | 185 bp | At TSS Multiome | 880 | |
| chr12:53,675,553–53,677,839 | 49.7 kb | Distal (>10kb) Multiome | 1104 | |
| chr12:53,696,162–53,696,648 | 70.1 kb | Distal (>10kb) Multiome | 228 | |
| chr12:53,727,002–53,728,055 | 101.2 kb | Distal (>10kb) Multiome | 768 | |
| chr12:53,738,393–53,738,964 | 112.3 kb | Distal (>10kb) Multiome | 131 | |
| chr12:53,746,454–53,746,954 | 120.4 kb | Distal (>10kb) Multiome | 503 | |
| chr12:53,756,873–53,757,721 | 131.0 kb | Distal (>10kb) Multiome | 367 |
Genomic view of the ATF7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.