Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF217. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF217 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF217, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:53,412,577–53,413,634 | 196.6 kb | Distal (>10kb) Multiome | 483 | |
| chr20:53,593,066–53,594,853 | 15.5 kb | Distal (>10kb) Multiome | 756 | |
| chr20:53,608,403–53,609,181 | 1.3 kb | Proximal (<10kb) Multiome | 386 | |
| chr20:53,609,537–53,609,895 | 11 bp | At TSS | 412 | |
| chr20:53,623,391–53,624,245 | 13.8 kb | Distal (>10kb) Multiome | 720 | |
| chr20:53,915,176–53,916,090 | 305.9 kb | Distal (>10kb) Multiome HiCAR | 707 | |
| chr20:53,918,946–53,919,429 | 309.2 kb | Distal (>10kb) Multiome HiCAR | 208 | |
| chr20:53,938,349–53,940,222 | 330.1 kb | Distal (>10kb) Multiome HiCAR | 696 | |
| chr20:53,942,064–53,942,654 | 332.4 kb | Distal (>10kb) Multiome HiCAR | 226 |
Genomic view of the ZNF217 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.