chr10:110,493,733–110,494,428

chr10 : 110,493,733 – 110,494,428

695 bp 112 TFs 6 linked genes

This 695 bp open chromatin element is linked to 6 target genes and is bound by 112 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
DUSP5-DT		1.8 kb	Proximal	Proximity
DUSP5		3.5 kb	Proximal	Proximity
SMC3		73.6 kb	Distal	Multiome
RBM20		150.3 kb	Distal	Multiome
SMNDC1		189.2 kb	Distal	Multiome
MXI1		286.5 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

112 transcription factors

ChIP prostate_fetal-fibroblast GSE90772.AR.prostate_fetal-fibroblast 315 bp overlap

ARID1B 1 dataset

ChIP K-562 ENCSR822CCM.ARID1B.K-562 386 bp overlap

ARID2 1 dataset

ChIP BIN-67_lentivirus-SMARCA4 GSE117734.ARID2.BIN-67_lentivirus-SMARCA4 324 bp overlap

Atoh1 1 dataset

Motif DE_36h DE_36h-Atoh1_MA1467.3 7 bp overlap

ChIP K-562_iBET-BD1-IFNG GSE138084.BRD3.K-562_iBET-BD1-IFNG 201 bp overlap

BRD4 7 datasets

ChIP CLL_patient1_4h_CpG_BET GSE109411.BRD4.CLL_patient1_4h_CpG_BET 155 bp overlap

ChIP CLL_patient3_4h_CpG GSE109411.BRD4.CLL_patient3_4h_CpG 149 bp overlap

ChIP CLL_patient4_4h_CpG GSE109411.BRD4.CLL_patient4_4h_CpG 234 bp overlap

ChIP K-562_iBET GSE138084.BRD4.K-562_iBET 280 bp overlap

ChIP K-562_iBET-BD1-IFNG GSE138084.BRD4.K-562_iBET-BD1-IFNG 212 bp overlap

ChIP K-562_iBET-IFNG GSE138084.BRD4.K-562_iBET-IFNG 204 bp overlap

ChIP MV4-11_DMSO GSE120715.BRD4.MV4-11_DMSO 114 bp overlap

CBFA2T2 1 dataset

ChIP K562 ENCFF963TXY 381 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 313 bp overlap

ChIP K562 ENCFF673OEZ 176 bp overlap

ChIP K-562 ENCSR077DKV.CREM.K-562 130 bp overlap

CTBP1 2 datasets

ChIP K-562 ENCSR201NQZ.CTBP1.K-562 497 bp overlap

ChIP K562 ENCFF403WPG 536 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF274GAT 251 bp overlap

Motif DE_36h DE_36h-Crx_MA0467.3 6 bp overlap

ChIP K-562 ENCSR219BXP.DPF2.K-562 394 bp overlap

ChIP K-562 ENCSR211LTF.EGR1.K-562 219 bp overlap

ChIP HEK293 ENCFF336LFH 479 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 387 bp overlap

ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 482 bp overlap

FEZF2 2 datasets

Motif DE_36h DE_36h-FEZF2_MA2341.1 8 bp overlap

Motif DE_36h DE_36h-FEZF2_MA2341.1 8 bp overlap

ChIP A549 ENCFF029EEU 293 bp overlap

FOXA2 1 dataset

ChIP DE DE-FOXA2-1 431 bp overlap

GATA1 4 datasets

ChIP HUDEP-2_30min GSE104676.GATA1.HUDEP-2_30min 92 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 262 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 230 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 231 bp overlap

GATA2 7 datasets

ChIP ESF GSE108408.GATA2.ESF 284 bp overlap

ChIP K-562 ENCSR000DKA.GATA2.K-562 442 bp overlap

ChIP K-562 ENCSR000EWG.GATA2.K-562 238 bp overlap

ChIP K562 ENCFF513FTZ 301 bp overlap

ChIP K562 ENCFF830LLA 527 bp overlap

ChIP K562 ENCFF830LLA 542 bp overlap

ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 151 bp overlap

GATA3 1 dataset

ChIP SK-N-SH ENCFF040SSB 365 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 533 bp overlap

ChIP DE DE-GATA4-2 616 bp overlap

ChIP foregut GSE117136.GATA4.foregut 439 bp overlap

GATA5 1 dataset

Motif DE_36h DE_36h-GATA5_MA0766.3 8 bp overlap

GATA6 13 datasets

ChIP DE DE-GATA6-1 523 bp overlap

ChIP DE DE-GATA6-2 551 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 536 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 542 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 456 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 686 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 645 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 548 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 551 bp overlap

ChIP foregut GSE117136.GATA6.foregut 451 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 471 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 259 bp overlap

GFI1B 1 dataset

ChIP K-562 ENCSR509GDT.GFI1B.K-562 186 bp overlap

GRHL2 1 dataset

Motif DE_36h DE_36h-GRHL2_MA1105.3 8 bp overlap

Motif DE_36h DE_36h-GSC_MA0648.2 6 bp overlap

Motif DE_36h DE_36h-GSC2_MA0891.2 6 bp overlap

Gata3 1 dataset

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

HAND2 1 dataset

Motif DE_36h DE_36h-HAND2_MA1638.2 6 bp overlap

HDAC1 3 datasets

ChIP K-562 ENCSR387UWP.HDAC1.K-562 326 bp overlap

ChIP K-562 ENCSR711VWL.HDAC1.K-562 291 bp overlap

ChIP K562 ENCFF968WBH 514 bp overlap

HDAC2 2 datasets

ChIP K-562 ENCSR893WSB.HDAC2.K-562 367 bp overlap

ChIP K-562 ENCSR075HTM.HDAC2.K-562 217 bp overlap

HMBOX1 1 dataset

ChIP K-562 ENCSR757IIU.HMBOX1.K-562 164 bp overlap

HNF4A 1 dataset

ChIP IM95 GSE114018.HNF4A.IM95 173 bp overlap

HNRNPK 1 dataset

ChIP primary-keratinocyte GSE122327.HNRNPK.primary-keratinocyte 180 bp overlap

HOXA7 2 datasets

ChIP A-549 ENCSR402OYZ.HOXA7.A-549 222 bp overlap

ChIP A549 ENCFF746ZBJ 331 bp overlap

ChIP keratinocyte_DOX GSE135677.IRF2.keratinocyte_DOX 236 bp overlap

Motif DE_36h DE_36h-Isl1_MA1608.2 7 bp overlap

ChIP A549 ENCFF846DUV 604 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 564 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 339 bp overlap

ChIP K-562 ENCSR000EFV.MAX.K-562 143 bp overlap

ChIP K562 ENCFF110LJS 351 bp overlap

MED26 1 dataset

ChIP HEK293T GSE121024.MED26.HEK293T 270 bp overlap

MLLT1 1 dataset

ChIP GM12878 ENCSR552XSN.MLLT1.GM12878 382 bp overlap

MSANTD3 1 dataset

Motif DE_36h DE_36h-MSANTD3_MA1523.2 7 bp overlap

ChIP K-562 ENCSR180NCY.MTA3.K-562 331 bp overlap

Motif DE_36h DE_36h-MXI1_MA1108.3 6 bp overlap

Motif DE_36h DE_36h-MZF1_MA0056.3 8 bp overlap

Msgn1 1 dataset

Motif DE_36h DE_36h-Msgn1_MA1524.3 10 bp overlap

NCOR1 1 dataset

ChIP K-562 ENCSR798ILC.NCOR1.K-562 252 bp overlap

NELFE 1 dataset

ChIP K-562_HS GSE112379.NELFE.K-562_HS 159 bp overlap

NEUROD1 2 datasets

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 255 bp overlap

Motif DE_36h DE_36h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 1 dataset

Motif DE_36h DE_36h-NEUROG2_MA1642.2 7 bp overlap

NKX2-5 1 dataset

ChIP hESC_ab3584 GSE89457.NKX2-5.hESC_ab3584 290 bp overlap

NKX6-3 1 dataset

Motif DE_36h DE_36h-NKX6-3_MA1530.2 8 bp overlap

NR2E3 1 dataset

ChIP A549 ENCFF833WDR 351 bp overlap

Neurod2 1 dataset

Motif DE_36h DE_36h-Neurod2_MA0668.3 8 bp overlap

Motif DE_36h DE_36h-OTX1_MA0711.2 6 bp overlap

Motif DE_36h DE_36h-OTX2_MA0712.3 7 bp overlap

ChIP HCT-116_ab20662 GSE97527.PAF1.HCT-116_ab20662 598 bp overlap

ChIP A-549 ENCSR637RKG.PBX1.A-549 282 bp overlap

PITX1 1 dataset

Motif DE_36h DE_36h-PITX1_MA0682.3 6 bp overlap

PITX2 1 dataset

Motif DE_36h DE_36h-PITX2_MA1547.2 8 bp overlap

PITX3 1 dataset

Motif DE_36h DE_36h-PITX3_MA0714.2 6 bp overlap

POLR2A 1 dataset

ChIP A549 ENCFF034EBG 474 bp overlap

Ptf1A 1 dataset

Motif DE_36h DE_36h-Ptf1A_MA1618.2 9 bp overlap

RAD21 2 datasets

ChIP HCT-116 GSE131606.RAD21.HCT-116 337 bp overlap

ChIP IMR-90 ENCSR000EFJ.RAD21.IMR-90 203 bp overlap

RARA::RXRA 1 dataset

Motif DE_36h DE_36h-RARARXRA_MA0159.1 17 bp overlap

RARA::RXRG 1 dataset

Motif DE_36h DE_36h-RARARXRG_MA1149.2 17 bp overlap

ChIP 786-O GSE86092.RELA.786-O 104 bp overlap

RHOXF1 1 dataset

Motif DE_36h DE_36h-RHOXF1_MA0719.2 6 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 207 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 665 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 628 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 427 bp overlap

SMAD2_3 4 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 342 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 456 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 514 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 560 bp overlap

SMAD3 2 datasets

Motif DE_36h DE_36h-SMAD3_MA0795.1 10 bp overlap

ChIP SUM159PT GSE130364.SMAD3.SUM159PT 419 bp overlap

SMAD4 2 datasets

ChIP K562 ENCFF628RBP 541 bp overlap

ChIP endoderm GSE29422.SMAD4.endoderm 197 bp overlap

SMAD5 1 dataset

Motif DE_36h DE_36h-SMAD5_MA1557.1 10 bp overlap

SMARCA4 2 datasets

ChIP K-562 ENCSR643VTW.SMARCA4.K-562 312 bp overlap

ChIP endometrial-epithelial-cells_KO GSE106660.SMARCA4.endometrial-epithelial-cells_KO 230 bp overlap

SMARCE1 1 dataset

ChIP K-562 ENCSR157TCS.SMARCE1.K-562 303 bp overlap

ChIP IMR-90 ENCSR000HPG.SMC3.IMR-90 217 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 257 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 365 bp overlap

SPI1 6 datasets

ChIP GM12891 ENCFF563IUT 241 bp overlap

ChIP GM12891 ENCSR000BIJ.SPI1.GM12891 147 bp overlap

ChIP K-562 ENCSR000BGW.SPI1.K-562 106 bp overlap

ChIP K-562_NABUT GSE74999.SPI1.K-562_NABUT 128 bp overlap

ChIP K-562_SAHA GSE74999.SPI1.K-562_SAHA 133 bp overlap

ChIP NCI-H929 GSE56857.SPI1.NCI-H929 105 bp overlap

SPIB 2 datasets

Motif DE_36h DE_36h-SPIB_MA0081.3 13 bp overlap

ChIP OCI-Ly3_SHCTR GSE56857.SPIB.OCI-Ly3_SHCTR 214 bp overlap

STAT3 1 dataset

ChIP HepaRG_sodium-oleate GSE89157.STAT3.HepaRG_sodium-oleate 171 bp overlap

SUPT5H 1 dataset

ChIP DLD-1_NELFCD-AID GSE144786.SUPT5H.DLD-1_NELFCD-AID 207 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 185 bp overlap

TAL1 2 datasets

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 149 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 142 bp overlap

TAL1::TCF3 1 dataset

Motif DE_36h DE_36h-TAL1TCF3_MA0091.2 10 bp overlap

TBX5 6 datasets

ChIP G296S GSE85628.TBX5.G296S 384 bp overlap

ChIP G296S_2 GSE85628.TBX5.G296S_2 384 bp overlap

ChIP G296S_4 GSE85628.TBX5.G296S_4 152 bp overlap

ChIP cardiomyocyte_5 GSE85628.TBX5.cardiomyocyte_5 229 bp overlap

ChIP cardiomyocyte_7 GSE85628.TBX5.cardiomyocyte_7 227 bp overlap

ChIP hiPSC GSE81585.TBX5.hiPSC 339 bp overlap

ChIP K-562 ENCSR970OJY.TCF3.K-562 218 bp overlap

TEAD1 1 dataset

ChIP keratinocyte GSE138727.TEAD1.keratinocyte 614 bp overlap

TERF1 1 dataset

ChIP LCL GSE55053.TERF1.LCL 162 bp overlap

TP63 11 datasets

ChIP BxPC-3 GSE115461.TP63.BxPC-3 300 bp overlap

ChIP MCF-10A_Nutlin3A GSE111009.TP63.MCF-10A_Nutlin3A 268 bp overlap

ChIP SUIT-2 GSE115461.TP63.SUIT-2 464 bp overlap

ChIP keratinocyte GSE56674.TP63.keratinocyte 253 bp overlap

ChIP keratinocyte_CISP GSE56674.TP63.keratinocyte_CISP 337 bp overlap

ChIP keratinocyte_D0 GSE59824.TP63.keratinocyte_D0 376 bp overlap

ChIP keratinocyte_D2 GSE59824.TP63.keratinocyte_D2 354 bp overlap

ChIP keratinocyte_D4 GSE59824.TP63.keratinocyte_D4 333 bp overlap

ChIP keratinocyte_D7 GSE59824.TP63.keratinocyte_D7 353 bp overlap

ChIP keratinocyte_epidermal GSE67382.TP63.keratinocyte_epidermal 242 bp overlap

ChIP keratinocyte_epidermal_KDPAF GSE67382.TP63.keratinocyte_epidermal_KDPAF 247 bp overlap

TRPS1 1 dataset

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

ChIP K-562 ENCSR000EFZ.UBTF.K-562 163 bp overlap

ChIP IMR-90 ENCSR513UQG.USF2.IMR-90 150 bp overlap

ZBTB40 1 dataset

ChIP K-562 ENCSR237VLT.ZBTB40.K-562 234 bp overlap

ZBTB7A 2 datasets

ChIP K-562 GSE103445.ZBTB7A.K-562 164 bp overlap

ChIP K-562 ENCSR000BME.ZBTB7A.K-562 171 bp overlap

ZEB2 2 datasets

ChIP K-562 ENCSR004GKA.ZEB2.K-562 581 bp overlap

ChIP K-562 ENCSR322CFO.ZEB2.K-562 238 bp overlap

ZFHX2 1 dataset

ChIP HEK293 ENCFF167TUA 240 bp overlap

ZKSCAN3 1 dataset

Motif DE_36h DE_36h-ZKSCAN3_MA1973.2 14 bp overlap

ZKSCAN5 1 dataset

Motif DE_36h DE_36h-ZKSCAN5_MA1652.2 9 bp overlap

ZNF134 2 datasets

ChIP K-562 ENCSR553NTC.ZNF134.K-562 462 bp overlap

ChIP K562 ENCFF502NWS 345 bp overlap

ZNF143 1 dataset

ChIP FLP76_T4 GSE39263.ZNF143.FLP76_T4 168 bp overlap

ZNF213 1 dataset

Motif DE_36h DE_36h-ZNF213_MA2121.1 12 bp overlap

ZNF274 1 dataset

Motif DE_36h DE_36h-ZNF274_MA1592.2 12 bp overlap

ZNF282 1 dataset

Motif DE_36h DE_36h-ZNF282_MA1154.2 15 bp overlap

ChIP K-562 ENCSR195QFV.ZNF3.K-562 414 bp overlap

ZNF534 1 dataset

ChIP HEK293T GSE78099.ZNF534.HEK293T 169 bp overlap

ZNF701 1 dataset

Motif DE_36h DE_36h-ZNF701_MA1987.2 17 bp overlap

Znf423 1 dataset

Motif DE_36h DE_36h-Znf423_MA0116.1 15 bp overlap