Transcription factors with Perturb-seq knockdown data for DUSP5-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUSP5-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUSP5-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:110,487,182–110,487,690 | 8.5 kb | Proximal (<10kb) | 254 | |
| chr10:110,488,982–110,489,343 | 6.9 kb | Proximal (<10kb) | 60 | |
| chr10:110,493,733–110,494,428 | 1.8 kb | Proximal (<10kb) | 112 | |
| chr10:110,495,938–110,496,644 | at TSS | At TSS | 295 | |
| chr10:110,497,303–110,499,967 | 1.1 kb | Proximal (<10kb) | 772 | |
| chr10:110,500,619–110,501,759 | 4.4 kb | Proximal (<10kb) | 529 | |
| chr10:110,502,162–110,502,495 | 6.0 kb | Proximal (<10kb) | 68 |
Genomic view of the DUSP5-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.