Transcription factors with Perturb-seq knockdown data for MSANTD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MSANTD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MSANTD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:99,221,253–99,222,741 | 1205.4 kb | Distal (>10kb) Multiome HiCAR | 903 | |
| chr9:100,352,182–100,353,419 | 74.5 kb | Distal (>10kb) Multiome | 937 | |
| chr9:100,411,250–100,412,233 | 15.7 kb | Distal (>10kb) Multiome | 544 | |
| chr9:100,426,556–100,428,087 | 124 bp | At TSS Multiome | 680 | |
| chr9:100,472,600–100,475,134 | 45.7 kb | Distal (>10kb) Multiome | 501 | |
| chr9:100,567,051–100,567,983 | 140.0 kb | Distal (>10kb) Multiome | 147 | |
| chr9:100,598,220–100,599,238 | 171.4 kb | Distal (>10kb) Multiome | 517 | |
| chr9:100,637,622–100,638,453 | 210.5 kb | Distal (>10kb) Multiome | 112 | |
| chr9:100,664,438–100,664,921 | 237.3 kb | Distal (>10kb) Multiome | 46 |
Genomic view of the MSANTD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.