Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF134. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF134 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF134, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:56,393,166–56,393,951 | 1220.7 kb | Distal (>10kb) Multiome HiCAR | 653 | |
| chr19:57,320,108–57,321,075 | 293.8 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,350,874–57,351,693 | 263.0 kb | Distal (>10kb) Multiome | 620 | |
| chr19:57,362,957–57,363,972 | 250.8 kb | Distal (>10kb) Multiome | 697 | |
| chr19:57,389,420–57,390,542 | 224.4 kb | Distal (>10kb) Multiome | 722 | |
| chr19:57,410,944–57,411,658 | 203.1 kb | Distal (>10kb) Multiome | 612 | |
| chr19:57,434,797–57,436,077 | 178.9 kb | Distal (>10kb) Multiome | 742 | |
| chr19:57,477,251–57,477,789 | 136.7 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 126.5 kb | Distal (>10kb) Multiome | 483 | |
| chr19:57,499,726–57,500,208 | 114.3 kb | Distal (>10kb) Multiome | 523 | |
| chr19:57,527,148–57,527,898 | 86.8 kb | Distal (>10kb) Multiome | 711 | |
| chr19:57,559,528–57,559,978 | 54.4 kb | Distal (>10kb) Multiome | 564 | |
| chr19:57,578,473–57,579,216 | 35.3 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,583,416–57,584,426 | 30.2 kb | Distal (>10kb) Multiome | 462 | |
| chr19:57,599,699–57,600,175 | 14.4 kb | Distal (>10kb) Multiome | 646 | |
| chr19:57,614,049–57,614,534 | 3 bp | At TSS Multiome | 661 | |
| chr19:57,632,786–57,633,679 | 18.9 kb | Distal (>10kb) Multiome | 652 | |
| chr19:57,681,556–57,682,393 | 67.7 kb | Distal (>10kb) Multiome | 724 | |
| chr19:57,708,682–57,709,450 | 95.0 kb | Distal (>10kb) Multiome | 199 | |
| chr19:57,727,326–57,727,941 | 113.4 kb | Distal (>10kb) Multiome | 400 | |
| chr19:57,746,610–57,747,111 | 132.6 kb | Distal (>10kb) Multiome | 625 | |
| chr19:57,769,422–57,770,058 | 155.4 kb | Distal (>10kb) Multiome | 509 | |
| chr19:57,803,547–57,804,316 | 189.7 kb | Distal (>10kb) Multiome | 206 | |
| chr19:57,804,773–57,805,214 | 190.8 kb | Distal (>10kb) Multiome | 37 | |
| chr19:57,810,480–57,811,177 | 196.6 kb | Distal (>10kb) Multiome | 180 | |
| chr19:57,814,439–57,815,270 | 200.7 kb | Distal (>10kb) Multiome | 692 | |
| chr19:57,819,268–57,819,991 | 205.4 kb | Distal (>10kb) Multiome | 734 | |
| chr19:57,829,187–57,830,712 | 216.0 kb | Distal (>10kb) Multiome | 321 | |
| chr19:57,849,421–57,850,221 | 235.5 kb | Distal (>10kb) Multiome | 291 | |
| chr19:57,887,264–57,887,897 | 273.4 kb | Distal (>10kb) Multiome | 47 | |
| chr19:57,888,389–57,889,457 | 274.8 kb | Distal (>10kb) Multiome | 322 | |
| chr19:58,150,278–58,150,941 | 536.5 kb | Distal (>10kb) Multiome HiCAR | 533 | |
| chr19:58,154,448–58,155,527 | 540.9 kb | Distal (>10kb) Multiome HiCAR | 802 |
Genomic view of the ZNF134 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.