Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF282. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF282 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF282, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:148,940,713–148,941,315 | 254.4 kb | Distal (>10kb) Multiome | 792 | |
| chr7:148,966,846–148,967,346 | 228.5 kb | Distal (>10kb) Multiome | 532 | |
| chr7:148,982,929–148,984,226 | 211.9 kb | Distal (>10kb) Multiome | 671 | |
| chr7:148,987,066–148,988,336 | 208.0 kb | Distal (>10kb) Multiome | 765 | |
| chr7:149,027,878–149,029,294 | 166.8 kb | Distal (>10kb) Multiome | 992 | |
| chr7:149,065,040–149,066,286 | 129.7 kb | Distal (>10kb) Multiome | 971 | |
| chr7:149,071,460–149,072,205 | 123.6 kb | Distal (>10kb) Multiome | 300 | |
| chr7:149,090,124–149,091,686 | 104.8 kb | Distal (>10kb) Multiome | 1010 | |
| chr7:149,125,518–149,127,217 | 69.2 kb | Distal (>10kb) Multiome | 1147 | |
| chr7:149,145,364–149,146,036 | 49.9 kb | Distal (>10kb) Multiome | 220 | |
| chr7:149,147,030–149,148,737 | 48.1 kb | Distal (>10kb) Multiome | 938 | |
| chr7:149,194,998–149,196,417 | 11 bp | At TSS Multiome | 917 | |
| chr7:149,239,406–149,240,188 | 44.1 kb | Distal (>10kb) Multiome | 889 | |
| chr7:149,261,689–149,262,807 | 66.6 kb | Distal (>10kb) Multiome | 905 | |
| chr7:149,284,774–149,286,087 | 89.7 kb | Distal (>10kb) Multiome | 499 | |
| chr7:149,355,344–149,356,078 | 160.2 kb | Distal (>10kb) Multiome | 329 | |
| chr7:149,414,692–149,415,889 | 219.6 kb | Distal (>10kb) Multiome | 271 | |
| chr7:149,421,846–149,422,651 | 226.9 kb | Distal (>10kb) Multiome | 665 | |
| chr7:149,459,399–149,461,328 | 265.1 kb | Distal (>10kb) Multiome | 734 |
Genomic view of the ZNF282 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.