This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for ARID1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARID1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARID1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:155,313,962–155,315,220 | 1462.7 kb | Distal (>10kb) Multiome HiCAR | 1066 | |
| chr6:156,556,716–156,558,143 | 219.8 kb | Distal (>10kb) Multiome HiCAR | 309 | |
| chr6:156,655,335–156,656,025 | 121.7 kb | Distal (>10kb) Multiome | 157 | |
| chr6:156,686,231–156,688,561 | 90.0 kb | Distal (>10kb) Multiome | 995 | |
| chr6:156,770,941–156,771,547 | 5.8 kb | Proximal (<10kb) | 52 | |
| chr6:156,775,126–156,775,266 | 2.1 kb | Proximal (<10kb) | 76 | |
| chr6:156,776,956–156,780,648 | 101 bp | At TSS Multiome | 985 | |
| chr6:156,784,130–156,784,326 | 6.8 kb | Proximal (<10kb) | 26 | |
| chr6:156,944,408–156,944,838 | 167.3 kb | Distal (>10kb) Multiome | 86 | |
| chr6:157,020,971–157,022,582 | 244.2 kb | Distal (>10kb) Multiome | 1105 |
Genomic view of the ARID1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.