Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in DNA damage response. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB40. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB40 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB40, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:22,154,320–22,155,232 | 297.0 kb | Distal (>10kb) Multiome | 103 | |
| chr1:22,442,329–22,443,072 | 9.2 kb | Proximal (<10kb) Multiome | 41 | |
| chr1:22,443,217–22,443,731 | 8.2 kb | Proximal (<10kb) Multiome | 29 | |
| chr1:22,451,358–22,452,630 | 15 bp | At TSS Multiome | 1027 | |
| chr1:22,456,784–22,456,971 | 4.9 kb | Proximal (<10kb) | 13 | |
| chr1:22,710,203–22,711,431 | 258.9 kb | Distal (>10kb) Multiome | 253 | |
| chr1:22,716,768–22,717,592 | 265.4 kb | Distal (>10kb) Multiome | 165 | |
| chr1:22,741,075–22,741,547 | 289.5 kb | Distal (>10kb) Multiome | 33 |
Genomic view of the ZBTB40 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.