chr11 : 105,914,911 – 105,915,658
747 bp 157 TFs 0 linked genes
This 747 bp open chromatin element has no linked target genes and is bound by 157 transcription factors.
Linked Genes
No linked genes
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr11:105,909,911 – 105,920,658
This element Other elements ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
157 transcription factors
Source
Cell type
ATF2 2 datasets
Motif DE_12h DE_12h-ATF2_MA1632.2 10 bp overlap
Motif DE_12h DE_12h-ATF2_MA1632.2 10 bp overlap
BACH2 2 datasets
Motif DE_12h DE_12h-BACH2_MA1101.3 11 bp overlap
Motif DE_12h DE_12h-BACH2_MA1470.2 19 bp overlap
BAP1 1 dataset
ChIP NCI-H1963_shNONT GSE145028.BAP1.NCI-H1963_shNONT 275 bp overlap
BARX1 1 dataset
Motif DE_12h DE_12h-BARX1_MA0875.2 6 bp overlap
BARX2 1 dataset
Motif DE_12h DE_12h-BARX2_MA1471.2 9 bp overlap
BCOR 1 dataset
ChIP WA01 GSE104690.BCOR.WA01 170 bp overlap
BRD4 1 dataset
ChIP MV4-11_IBET151_5000nM GSE120715.BRD4.MV4-11_IBET151_5000nM 189 bp overlap
BSX 1 dataset
Motif DE_12h DE_12h-BSX_MA0876.2 6 bp overlap
CHD7 1 dataset
ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 560 bp overlap
CTCF 14 datasets
Motif DE_12h DE_12h-CTCF_MA1929.2 31 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF230SFD 517 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF267VHH 501 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF277CZQ 505 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF282ONV 485 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF327VLN 505 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF373BUI 397 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF433UFM 545 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF458OBF 511 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF478RRB 431 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF595WAL 491 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF748IBN 517 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF749FBO 477 bp overlap
ChIP dorsolateral prefrontal cortex ENCFF883PFA 437 bp overlap
DLX1 1 dataset
Motif DE_12h DE_12h-DLX1_MA0879.3 6 bp overlap
DLX6 1 dataset
Motif DE_12h DE_12h-DLX6_MA0882.2 6 bp overlap
DMRTC2 1 dataset
Motif DE_12h DE_12h-DMRTC2_MA1479.2 11 bp overlap
Dlx3 1 dataset
Motif DE_12h DE_12h-Dlx3_MA0880.2 6 bp overlap
Dlx4 1 dataset
Motif DE_12h DE_12h-Dlx4_MA0881.2 6 bp overlap
EED 1 dataset
ChIP ProEs GSE59087.EED.ProEs 186 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 184 bp overlap
ERF::FOXI1 1 dataset
Motif DE_12h DE_12h-ERFFOXI1_MA1935.2 10 bp overlap
ESR1 2 datasets
ChIP Ishikawa ENCSR000BQR.ESR1.Ishikawa 188 bp overlap
ChIP Ishikawa_ETV4-KO2_Mili GSE129803.ESR1.Ishikawa_ETV4-KO2_Mili 172 bp overlap
FLI1::FOXI1 1 dataset
Motif DE_12h DE_12h-FLI1FOXI1_MA1950.2 11 bp overlap
FOS 1 dataset
Motif DE_12h DE_12h-FOS_MA1951.2 13 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 581 bp overlap
ChIP DE DE-FOXA2-2 567 bp overlap
FOXD3 1 dataset
Motif DE_12h DE_12h-FOXD3_MA0041.3 14 bp overlap
FOXE1 1 dataset
Motif DE_12h DE_12h-FOXE1_MA1487.3 12 bp overlap
FOXF2 1 dataset
Motif DE_12h DE_12h-FOXF2_MA0030.2 9 bp overlap
FOXG1 1 dataset
Motif DE_12h DE_12h-FOXG1_MA0613.1 8 bp overlap
FOXH1 1 dataset
Motif DE_12h DE_12h-FOXH1_MA0479.2 8 bp overlap
FOXK1 1 dataset
Motif DE_12h DE_12h-FOXK1_MA0852.3 7 bp overlap
FOXK2 1 dataset
Motif DE_12h DE_12h-FOXK2_MA1103.3 7 bp overlap
FOXL1 1 dataset
Motif DE_12h DE_12h-FOXL1_MA0033.2 7 bp overlap
FOXN3 2 datasets
Motif DE_12h DE_12h-FOXN3_MA1489.1 8 bp overlap
Motif DE_12h DE_12h-FOXN3_MA1489.1 8 bp overlap
FOXO1::ELF1 1 dataset
Motif DE_12h DE_12h-FOXO1ELF1_MA1953.2 13 bp overlap
FOXO1::ELK1 1 dataset
Motif DE_12h DE_12h-FOXO1ELK1_MA1954.2 13 bp overlap
FOXO4 1 dataset
Motif DE_12h DE_12h-FOXO4_MA0848.1 7 bp overlap
FOXO6 1 dataset
Motif DE_12h DE_12h-FOXO6_MA0849.1 7 bp overlap
FOXP1 1 dataset
ChIP H9 GSE31006.FOXP1.H9 201 bp overlap
FOXP2 1 dataset
Motif DE_12h DE_12h-FOXP2_MA0593.2 9 bp overlap
FOXP3 1 dataset
Motif DE_12h DE_12h-FOXP3_MA0850.1 7 bp overlap
Foxf1 1 dataset
Motif DE_12h DE_12h-Foxf1_MA1606.2 7 bp overlap
Foxj2 1 dataset
Motif DE_12h DE_12h-Foxj2_MA0614.1 8 bp overlap
Foxj3 1 dataset
Motif DE_12h DE_12h-Foxj3_MA0851.2 9 bp overlap
Foxo1 1 dataset
Motif DE_12h DE_12h-Foxo1_MA0480.3 7 bp overlap
Foxo3 1 dataset
Motif DE_12h DE_12h-Foxo3_MA0157.4 7 bp overlap
Foxq1 1 dataset
Motif DE_12h DE_12h-Foxq1_MA0040.2 10 bp overlap
GABPA 1 dataset
ChIP VCaP_ETOH GSE49091.GABPA.VCaP_ETOH 126 bp overlap
GATA4 2 datasets
ChIP DE DE-GATA4-1 580 bp overlap
ChIP DE DE-GATA4-2 573 bp overlap
GATA6 7 datasets
ChIP DE DE-GATA6-1 389 bp overlap
ChIP DE DE-GATA6-2 502 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 318 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 307 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 487 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 335 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 345 bp overlap
GBX2 1 dataset
Motif DE_12h DE_12h-GBX2_MA0890.2 6 bp overlap
HAND2 1 dataset
Motif DE_12h DE_12h-HAND2_MA1638.2 6 bp overlap
HDAC2 1 dataset
ChIP H1 ENCFF939VKA 237 bp overlap
HESX1 1 dataset
Motif DE_12h DE_12h-HESX1_MA0894.2 6 bp overlap
HIC2 1 dataset
Motif DE_12h DE_12h-HIC2_MA0738.2 6 bp overlap
HOXA7 1 dataset
Motif DE_12h DE_12h-HOXA7_MA1498.3 6 bp overlap
HOXB13 1 dataset
Motif DE_12h DE_12h-HOXB13_MA0901.3 9 bp overlap
Hand1::Tcf3 1 dataset
Motif DE_12h DE_12h-Hand1Tcf3_MA0092.2 9 bp overlap
Hmx2 1 dataset
Motif DE_12h DE_12h-Hmx2_MA0897.2 15 bp overlap
Hnf1A 1 dataset
Motif DE_12h DE_12h-Hnf1A_MA1991.2 10 bp overlap
IKZF1 1 dataset
Motif DE_12h DE_12h-IKZF1_MA1508.2 8 bp overlap
IRF3 1 dataset
Motif DE_12h DE_12h-IRF3_MA1418.2 17 bp overlap
IRF7 2 datasets
Motif DE_12h DE_12h-IRF7_MA0772.2 13 bp overlap
Motif DE_12h DE_12h-IRF7_MA0772.2 13 bp overlap
IRF9 1 dataset
Motif DE_12h DE_12h-IRF9_MA0653.1 15 bp overlap
Irf1 2 datasets
Motif DE_12h DE_12h-Irf1_MA0050.4 11 bp overlap
Motif DE_12h DE_12h-Irf1_MA0050.4 11 bp overlap
JDP2 1 dataset
Motif DE_12h DE_12h-JDP2_MA0655.1 9 bp overlap
JUN 5 datasets
Motif DE_12h DE_12h-JUN_MA0488.2 10 bp overlap
ChIP DE_D1 S08-DE-d1-JUN-exp1 351 bp overlap
ChIP DE_D1 S40-DE-d1-JUN-exp2 345 bp overlap
ChIP DE_D2 S02-DE-d2-JUN-exp1 256 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 433 bp overlap
JUND 2 datasets
Motif DE_12h DE_12h-JUND_MA0491.3 9 bp overlap
Motif DE_12h DE_12h-JUND_MA0492.2 11 bp overlap
LBX2 1 dataset
Motif DE_12h DE_12h-LBX2_MA0699.2 6 bp overlap
LHX2 1 dataset
Motif DE_12h DE_12h-LHX2_MA0700.3 6 bp overlap
Lef1 1 dataset
Motif DE_12h DE_12h-Lef1_MA0768.3 8 bp overlap
MED1 1 dataset
ChIP LNCaP_Veh GSE125245.MED1.LNCaP_Veh 131 bp overlap
MEF2C 1 dataset
Motif DE_12h DE_12h-MEF2C_MA0497.2 11 bp overlap
MEIS1 3 datasets
Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap
Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap
Motif DE_12h DE_12h-MEIS1_MA1639.2 9 bp overlap
MSX1 1 dataset
Motif DE_12h DE_12h-MSX1_MA0666.3 6 bp overlap
MSX2 1 dataset
Motif DE_12h DE_12h-MSX2_MA0708.3 6 bp overlap
Msx3 1 dataset
Motif DE_12h DE_12h-Msx3_MA0709.2 6 bp overlap
NANOG 7 datasets
ChIP HUES-8 GSE109524.NANOG.HUES-8 458 bp overlap
ChIP WA01 ERP004238.NANOG.WA01 460 bp overlap
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 444 bp overlap
ChIP WA09 GSE105028.NANOG.WA09 389 bp overlap
ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 493 bp overlap
ChIP hESC GSE20650.NANOG.hESC 156 bp overlap
ChIP hESC GSE18292.NANOG.hESC 151 bp overlap
NEUROG2 1 dataset
Motif DE_12h DE_12h-NEUROG2_MA1642.2 7 bp overlap
NFE2 1 dataset
Motif DE_12h DE_12h-NFE2_MA0841.2 10 bp overlap
NR2C1 1 dataset
Motif DE_12h DE_12h-NR2C1_MA1535.2 6 bp overlap
NR2C2 1 dataset
Motif DE_12h DE_12h-NR2C2_MA1536.2 6 bp overlap
Nfatc2 1 dataset
Motif DE_12h DE_12h-Nfatc2_MA0152.3 8 bp overlap
Nobox 1 dataset
Motif DE_12h DE_12h-Nobox_MA0125.2 6 bp overlap
Nr1H2 1 dataset
Motif DE_12h DE_12h-Nr1H2_MA1996.2 6 bp overlap
Nr1H4 1 dataset
Motif DE_12h DE_12h-Nr1H4_MA1110.3 6 bp overlap
Nr1h3 1 dataset
Motif DE_12h DE_12h-Nr1h3_MA2337.1 6 bp overlap
Nr2F6 1 dataset
Motif DE_12h DE_12h-Nr2F6_MA0728.1 15 bp overlap
PATZ1 1 dataset
Motif DE_12h DE_12h-PATZ1_MA1961.2 11 bp overlap
PAX3 1 dataset
Motif DE_12h DE_12h-PAX3_MA0780.1 10 bp overlap
POU4F1 1 dataset
Motif DE_12h DE_12h-POU4F1_MA0790.2 12 bp overlap
POU4F2 3 datasets
Motif DE_12h DE_12h-POU4F2_MA0683.2 15 bp overlap
Motif DE_12h DE_12h-POU4F2_MA0683.2 15 bp overlap
ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 166 bp overlap
POU4F3 1 dataset
Motif DE_12h DE_12h-POU4F3_MA0791.2 12 bp overlap
POU5F1 2 datasets
ChIP HUES-8 GSE109524.POU5F1.HUES-8 437 bp overlap
ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 532 bp overlap
PRDM9 2 datasets
Motif DE_12h DE_12h-PRDM9_MA1723.2 20 bp overlap
Motif DE_12h DE_12h-PRDM9_MA1723.2 20 bp overlap
Pax7 1 dataset
Motif DE_12h DE_12h-Pax7_MA0680.3 10 bp overlap
Ptf1A 1 dataset
Motif DE_12h DE_12h-Ptf1A_MA1618.2 9 bp overlap
RARA 1 dataset
Motif DE_12h DE_12h-RARA_MA0729.1 18 bp overlap
RAX 1 dataset
Motif DE_12h DE_12h-RAX_MA0718.2 6 bp overlap
RXRB 1 dataset
Motif DE_12h DE_12h-RXRB_MA0855.1 14 bp overlap
RXRG 1 dataset
Motif DE_12h DE_12h-RXRG_MA0856.1 14 bp overlap
Rarg 1 dataset
Motif DE_12h DE_12h-Rarg_MA0859.2 15 bp overlap
SMAD2 4 datasets
ChIP endoderm GSE29422.SMAD2.endoderm 198 bp overlap
ChIP hESC GSE29422.SMAD2.hESC 164 bp overlap
ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 469 bp overlap
ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 346 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 708 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 642 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 660 bp overlap
SMAD2_3 5 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 454 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 547 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 579 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 563 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 625 bp overlap
SMARCA4 4 datasets
ChIP NPC_siCT GSE122631.SMARCA4.NPC_siCT 426 bp overlap
ChIP NPC_siSOX GSE122631.SMARCA4.NPC_siSOX 343 bp overlap
ChIP hiPSC GSE124903.SMARCA4.hiPSC 577 bp overlap
ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 252 bp overlap
SMARCB1 2 datasets
ChIP hiPSC GSE124903.SMARCB1.hiPSC 662 bp overlap
ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 259 bp overlap
SMARCC1 3 datasets
ChIP DE_D1 S10-DE-d1-BAF155-exp1 258 bp overlap
ChIP hiPSC GSE124903.SMARCC1.hiPSC 715 bp overlap
ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 314 bp overlap
SOX10 1 dataset
Motif DE_12h DE_12h-SOX10_MA0442.3 6 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 278 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 229 bp overlap
SOX18 2 datasets
Motif DE_12h DE_12h-SOX18_MA1563.2 8 bp overlap
Motif DE_12h DE_12h-SOX18_MA1563.2 8 bp overlap
SOX2 2 datasets
ChIP HNSC GSE69479.SOX2.HNSC 747 bp overlap
ChIP hiPSC GSE56567.SOX2.hiPSC 380 bp overlap
SOX4 2 datasets
Motif DE_12h DE_12h-SOX4_MA0867.3 8 bp overlap
Motif DE_12h DE_12h-SOX4_MA0867.3 8 bp overlap
SOX8 1 dataset
Motif DE_12h DE_12h-SOX8_MA0868.3 7 bp overlap
SOX9 1 dataset
Motif DE_12h DE_12h-SOX9_MA0077.2 8 bp overlap
SP5 1 dataset
Motif DE_12h DE_12h-SP5_MA1965.2 6 bp overlap
SPIB 1 dataset
Motif DE_12h DE_12h-SPIB_MA0081.3 13 bp overlap
SPIC 2 datasets
Motif DE_12h DE_12h-SPIC_MA0687.2 13 bp overlap
Motif DE_12h DE_12h-SPIC_MA0687.2 13 bp overlap
SREBF1 1 dataset
Motif DE_12h DE_12h-SREBF1_MA0829.3 10 bp overlap
SREBF2 1 dataset
Motif DE_12h DE_12h-SREBF2_MA0596.1 10 bp overlap
SRY 2 datasets
Motif DE_12h DE_12h-SRY_MA0084.2 7 bp overlap
Motif DE_12h DE_12h-SRY_MA0084.2 7 bp overlap
STAT1 1 dataset
Motif DE_12h DE_12h-STAT1_MA0137.4 9 bp overlap
STAT1::STAT2 1 dataset
Motif DE_12h DE_12h-STAT1STAT2_MA0517.2 13 bp overlap
Sox11 1 dataset
Motif DE_12h DE_12h-Sox11_MA0869.3 8 bp overlap
Sox17 1 dataset
Motif DE_12h DE_12h-Sox17_MA0078.3 10 bp overlap
Sox5 1 dataset
Motif DE_12h DE_12h-Sox5_MA0087.3 8 bp overlap
Sox6 1 dataset
Motif DE_12h DE_12h-Sox6_MA0515.1 10 bp overlap
Sox7 1 dataset
Motif DE_12h DE_12h-Sox7_MA2095.1 10 bp overlap
Spi1 1 dataset
Motif DE_12h DE_12h-Spi1_MA0080.7 13 bp overlap
Stat2 2 datasets
Motif DE_12h DE_12h-Stat2_MA1623.2 10 bp overlap
Motif DE_12h DE_12h-Stat2_MA1623.2 10 bp overlap
Stat4 1 dataset
Motif DE_12h DE_12h-Stat4_MA0518.2 10 bp overlap
Stat5a::Stat5b 1 dataset
Motif DE_12h DE_12h-Stat5aStat5b_MA0519.2 9 bp overlap
T 1 dataset
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 278 bp overlap
TAL1::TCF3 1 dataset
Motif DE_12h DE_12h-TAL1TCF3_MA0091.2 10 bp overlap
TCF7L2 1 dataset
Motif DE_12h DE_12h-TCF7L2_MA0523.2 9 bp overlap
TWIST1 1 dataset
Motif DE_12h DE_12h-TWIST1_MA1123.3 8 bp overlap
Yy1 1 dataset
Motif DE_12h DE_12h-Yy1_MA0095.4 8 bp overlap
ZBTB18 1 dataset
Motif DE_12h DE_12h-ZBTB18_MA0698.2 11 bp overlap
ZIC1 1 dataset
Motif DE_12h DE_12h-ZIC1_MA0696.1 14 bp overlap
ZIC4 1 dataset
Motif DE_12h DE_12h-ZIC4_MA0751.2 14 bp overlap
ZIC5 1 dataset
Motif DE_12h DE_12h-ZIC5_MA1584.2 15 bp overlap
ZIM3 1 dataset
Motif DE_12h DE_12h-ZIM3_MA1709.2 11 bp overlap
ZKSCAN5 1 dataset
Motif DE_12h DE_12h-ZKSCAN5_MA1652.2 9 bp overlap
ZNF135 1 dataset
Motif DE_12h DE_12h-ZNF135_MA1587.1 14 bp overlap
ZNF214 1 dataset
Motif DE_12h DE_12h-ZNF214_MA1975.2 13 bp overlap
ZNF281 1 dataset
Motif DE_12h DE_12h-ZNF281_MA1630.3 10 bp overlap
ZNF317 2 datasets
Motif DE_12h DE_12h-ZNF317_MA1593.2 8 bp overlap
Motif DE_12h DE_12h-ZNF317_MA1593.2 8 bp overlap
ZNF331 1 dataset
Motif DE_12h DE_12h-ZNF331_MA1726.2 10 bp overlap
ZNF354A 1 dataset
Motif DE_12h DE_12h-ZNF354A_MA1978.2 20 bp overlap
ZNF384 1 dataset
Motif DE_12h DE_12h-ZNF384_MA1125.2 8 bp overlap
ZNF524 1 dataset
Motif DE_12h DE_12h-ZNF524_MA2096.1 9 bp overlap
ZNF549 1 dataset
Motif DE_12h DE_12h-ZNF549_MA1728.2 8 bp overlap
ZNF675 1 dataset
Motif DE_12h DE_12h-ZNF675_MA1714.2 19 bp overlap
ZNF701 1 dataset
Motif DE_12h DE_12h-ZNF701_MA1987.2 17 bp overlap
ZNF816 1 dataset
Motif DE_12h DE_12h-ZNF816_MA1719.2 15 bp overlap
ZNF85 1 dataset
Motif DE_12h DE_12h-ZNF85_MA1720.2 12 bp overlap
Zic1::Zic2 2 datasets
Motif DE_12h DE_12h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_12h DE_12h-Zic1Zic2_MA1628.2 7 bp overlap
Zic2 2 datasets
Motif DE_12h DE_12h-Zic2_MA1629.2 9 bp overlap
Motif DE_12h DE_12h-Zic2_MA1629.2 9 bp overlap
Zic3 2 datasets
Motif DE_12h DE_12h-Zic3_MA0697.3 7 bp overlap
Motif DE_12h DE_12h-Zic3_MA0697.3 7 bp overlap
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