Enables sequence-specific double-stranded DNA binding activity. Involved in primary adaptive immune response involving T cells and B cells. Located in cytosol and nucleoplasm. Part of RNA polymerase II transcription regulator complex. Implicated in immunodeficiency 60. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BACH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BACH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BACH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:90,216,039–90,216,540 | 1.7 kb | Proximal (<10kb) | 151 | |
| chr6:90,218,074–90,219,468 | 395 bp | At TSS Multiome | 622 | |
| chr6:90,294,706–90,297,702 | 78.7 kb | Distal (>10kb) Multiome | 679 | |
| chr6:90,385,858–90,387,296 | 167.9 kb | Distal (>10kb) Multiome | 295 | |
| chr6:90,479,062–90,479,622 | 261.2 kb | Distal (>10kb) Multiome HiCAR | 421 | |
| chr6:90,494,141–90,494,851 | 276.2 kb | Distal (>10kb) Multiome | 92 |
Genomic view of the BACH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.