This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for POU4F3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POU4F3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POU4F3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:146,331,495–146,331,720 | 7.1 kb | Proximal (<10kb) | 76 | |
| chr5:146,334,059–146,334,583 | 4.3 kb | Proximal (<10kb) | 70 | |
| chr5:146,337,335–146,337,869 | 968 bp | At TSS | 27 | |
| chr5:146,338,076–146,339,360 | at TSS | At TSS | 195 | |
| chr5:146,340,414–146,340,805 | 1.6 kb | Proximal (<10kb) | 363 | |
| chr5:146,343,123–146,343,922 | 4.3 kb | Proximal (<10kb) | 90 | |
| chr5:146,344,641–146,346,403 | 5.8 kb | Proximal (<10kb) | 236 |
Genomic view of the POU4F3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.