This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for POU4F1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POU4F1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POU4F1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:78,593,896–78,594,535 | 9.0 kb | Proximal (<10kb) | 145 | |
| chr13:78,595,488–78,596,692 | 6.9 kb | Proximal (<10kb) | 312 | |
| chr13:78,597,128–78,597,471 | 6.1 kb | Proximal (<10kb) | 86 | |
| chr13:78,601,064–78,602,096 | 1.5 kb | Proximal (<10kb) | 114 | |
| chr13:78,602,275–78,603,984 | at TSS | At TSS | 557 | |
| chr13:78,605,182–78,605,825 | 1.6 kb | Proximal (<10kb) | 185 | |
| chr13:78,606,929–78,609,079 | 3.4 kb | Proximal (<10kb) | 288 | |
| chr13:78,609,288–78,610,091 | 5.7 kb | Proximal (<10kb) | 176 |
Genomic view of the POU4F1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.