This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for ZBTB18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:243,848,989–243,851,603 | 197.8 kb | Distal (>10kb) Multiome | 630 | |
| chr1:243,917,045–243,917,829 | 131.1 kb | Distal (>10kb) Multiome | 409 | |
| chr1:244,047,471–244,050,335 | 174 bp | At TSS Multiome | 939 | |
| chr1:244,050,906–244,051,470 | 2.4 kb | Proximal (<10kb) | 219 | |
| chr1:244,052,069–244,052,658 | 3.5 kb | Proximal (<10kb) | 194 | |
| chr1:244,054,108–244,055,007 | 5.9 kb | Proximal (<10kb) Multiome | 151 | |
| chr1:244,056,664–244,056,907 | 8.1 kb | Proximal (<10kb) | 37 | |
| chr1:244,210,968–244,211,448 | 162.7 kb | Distal (>10kb) Multiome | 197 | |
| chr1:244,341,454–244,342,356 | 293.2 kb | Distal (>10kb) Multiome | 361 |
Genomic view of the ZBTB18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.