JDP2

Jun dimerization protein 2 | JUNDM2

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC3

Biological processes 27 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cAMP response element binding (GO:0035497)chromatin (GO:0000785)chromatin binding (GO:0003682)histone chaperone activity (GO:0140713)histone deacetylase binding (GO:0042826)leucine zipper domain binding (GO:0043522)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating JDP2 0 TFs

Transcription factors with Perturb-seq knockdown data for JDP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JDP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to JDP2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JDP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:75,176,098–75,177,235	251.0 kb	Distal (>10kb) Multiome	975
chr14:75,258,653–75,259,760	168.7 kb	Distal (>10kb) Multiome	840
chr14:75,276,919–75,277,969	150.6 kb	Distal (>10kb) Multiome	731
chr14:75,278,060–75,280,702	149.2 kb	Distal (>10kb) Multiome	928
chr14:75,293,606–75,295,425	133.5 kb	Distal (>10kb) Multiome	759
chr14:75,295,693–75,296,382	131.6 kb	Distal (>10kb) Multiome	471
chr14:75,419,070–75,419,695	8.3 kb	Proximal (<10kb) Multiome	358
chr14:75,427,222–75,428,490	99 bp	At TSS Multiome	640
chr14:75,452,945–75,453,577	25.5 kb	Distal (>10kb) Multiome	408
chr14:75,577,727–75,579,221	150.7 kb	Distal (>10kb) Multiome	646
chr14:75,660,453–75,661,746	233.3 kb	Distal (>10kb) Multiome	786

Genome Browser

Genomic view of the JDP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.